The effect of low FODMAP (Fermentable, Oligo-, Di-, Mono-saccharides and Polyols) diet with glutamine supplement versus placebo on clinical outcomes, quality of life and intestinal permeability in patients with irritable bowel syndrome

Shahid Beheshti University of Medical Sciences0 个研究点目标入组 50 人开始时间: 待定最近更新: 2021年2月22日

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•Patients with irritable bowel syndrome, according to a gastroenterologist diagnosed according to ROME IV criteria (having at least one day a week over the past 3 months for at least two of the following: 1- related to Defecation; 2- related to the frequency of defecation, 3- related to changes in stool shape and consistency, and no pathological findings in gastrointestinal
•Body Mass Index in range (18-25)
•Lack of any organic intestinal disease ( diagnosed by last 5 years ago colonoscopy) and intestinal infection (diagnosed by stool culture)
•Lack of medical history of chronic gastrointestinal and colorectal disease
•Lack of any major bowel surgery
•Lack of medical history of liver disorders
•Absence of regular use of laxatives or antidiarrheal drugs
•No chronic use of corticosteroids and immunosuppressants
•No usage of drugs that modifying the digestive motility such as metoclopramide, cisapride, diphenoxylate
•No usage of drugs that increased bleeding of intestinal mucosa such as aspirin, warfarin and heparin
•Absence of nicotine and its derivatives use in the last 6 months
•No usage of NSAIDs and aspirin in last week (influence on gut permeability)
•Absence of severe mental or behavioral disorder
•Lack of medical history of kidney disorders

•Not agree to entering the study
•Consumption of artificial sweeteners (effect on intestinal permeability) 2 days before entering the study

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