Comparing the Serum Vitamin D Levels and Pregnancy Rates in Women Undergoing Elective Frozen Embryo Transfer (eFET)
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- clinical pregnancy rate
研究概览
简要总结
The aim of this study is determining the affects of serum vitamin D levels to implantation and clinical pregnancy rates in women undergoing elective vitrified/thawed embryo transfer. Two groups will be identified according to the serum vitamin D levels on eFET transfer day and later on implantation, clinical pregnancy and ongoing pregnancy rates will be compared between those groups
详细描述
In the last decade there have been growing evidence about Vitamin D receptors and their role in female genital tract. But these studies are yet not well designed and the results should be interpreted cautiously. Although some of these studies advocating the Vitamin D deficiency as an negative circumstance on pregnancy rates some of the others don't agree. According to contradictory results understanding the actual role of those receptors needs more observation.
Latest retrospective analyse postulated that, vitamin D deficiency in fresh single embryo transfer cycles may reduce pregnancy rates mediated by endometrium or ovarian reserve and stimulation characteristics.
For this reason the investigators aimed to explore the effect of serum Vitamin D levels on pregnancy rates in infertile population undergoing frozen embryo transfer.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •18 years to 35 years age, a frozen ET with 1 Day 5 (blastocyst stage) embryo
- •Infertile women undergoing ICSI (intracytoplasmic sperm injection) cycle
- •Factors affecting fertility are Tubal
- •Unexplained or ovulatory disturbances,
排除标准
- •Need to do Preimplantation Genetic Diagnosis
- •Presence of endometriosis and adenomyosis
- •Severe male factor infertility
结局指标
主要结局
clinical pregnancy rate
时间窗: 4 weeks after embryo transfer
The presence of intrauterine gestational sac at 7 weeks of gestation
次要结局
- ongoing pregnancy rates(18 weeks after embryo transfer)
- implantation rates(3 weeks after embryo transfer)
研究者
C CELİK
Associate Professor
Bahceci Clinic