Postprandial Secretion of of Incretin Hormones and Incretin Effect in Patients With Maturity-onset Diabetes of the Young (MODY)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 31
- 试验地点
- 1
- 主要终点
- Incretin effect
研究概览
简要总结
The purpose of this study is to describe the incretin effect and postprandial incretin response in patients with MODY2 and MODY3 and a group of matched healthy subjects. In sulphonyl urea treated subjects the purpose is also to compare the incretin effect with and without treatment. In healthy subjects the purpose is also to investigate the incretin effect under increased levels of endogen incretin hormones.
详细描述
Comparison of of insulin secretion (AUC) during the experimental days. Furthermore a comparison of GIP, GLP1 and glucagon responses as well as plasma glucose levels.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Caucasians above 18 years
- •BMI > 19 kg/m2
- •Negative pancreatic beta cell- and glutamate decarboxylase-65(GAD65)- autoantibodies
- •Normal haemoglobin
- •Normal bloodpressure
- •Informed concent
排除标准
- •Known liver disease or affected liver enzymes (ALAT/ASAT >2 x upper normal limit)
- •Nephropathy (see creatinine> 130 μM and / or albuminuria)
- •Treatment with medications that cannot be discontinued for 12 hours
- •Any condition that the investigators feel would interfere with trial participation
- •Pregnancy or lactation
结局指标
主要结局
Incretin effect
时间窗: Within 1 year
The difference in insulin responses, as assessed by the area under curve (AUC) for plasma insulin and C-peptide concentrations, during the two different glucose stimuli: OGTT and isoglycemic iv glucose infusion aswell as after a test meal in MODY-patients compared to healthy control subjects.
次要结局
- Plasma GLP1 response(Within 1 year)
- Plasma GIP response(Within 1 year)
- Plasma glucagon response(Within 1 year)
研究者
Signe H Østoft, MD
MD
University Hospital, Gentofte, Copenhagen