Effects of Music-with-Movement (simultaneous Cognitive-motor Dual-task Training) on Cognitive and Physical Performance of People with Potentially Reversible Cognitive Frailty: a Randomised Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 113
- 试验地点
- 1
- 主要终点
- Montreal Cognitive Assessment
研究概览
简要总结
This study aims to evaluate the effects of Music-with-Movement Simultaneous Cognitive-Motor Dual-Task Training (MM-SDTT) on cognitive and physical performance in older adults with cognitive frailty coexisting with mild cognitive impairment (MCI) and physical frailty.
Research Questions:
- Will the treatment group show greater improvement in global cognitive functions than the social control group at Week 16?
- Will the treatment group show greater improvements in both cognitive, physical performance and psychosocial well-being than the social control group at Weeks 16 and 28?
Methodology:
Participants in the Treatment Group:
- Undergo a 16-week intervention comprising:
- Once-weekly center-based training supervised by a physical coach
- Twice-weekly home-based training using provided training videos
Participants in the Social Control Group:
- Engage in once-weekly social gatherings and receive remedial training after data collection is completed.
详细描述
There is a need to enhance the well-being of older adults with cognitive frailty, defined as the coexistence of mild cognitive impairment (MCI) and physical frailty. Literature shows that combining physical training with cognitive training is effective to improve the health outcomes of MCI, while whether it is beneficial to those MCI with co-existing physical frailty is unknown.
The proposed 16-week Music-with-Movement Simultaneous Cognitive-Motor Dual-Task Training (MM-SDTT) aims to evaluate its effects on the cognitive and physical performance of older adults with cognitive frailty. The MM-SDTT is designed to engage participants through music with cognitive and physical training. The intervention will include warm-up exercise, rhythmic marching, singing familiar songs, dancing workout, stretching exercise with relaxing music, and cool-down exercise. The intervention protocol has been designed according to the guidelines of the American College of Sports Medicine and evidence of previous music-with-movement intervention research.
The study will recruit older adults aged 60 and above, who live in the community and can walk independently, and also have cognitive frailty. Participants will be randomly assigned to either the treatment group or a social control group. Participants in the treatment group will undergo 16-week MM-SDTT consisting of once-weekly center-based training supervised by a coach and twice-weekly home-based training with provided training videos. The logbook and wearable sensor will be used as tools to monitor and record physical activity. Participants in the social control group will participate in social gatherings once weekly over the 16 weeks without affecting the usual care. The MM-SDTT is expected to improve the cognitive and physical functions of older adults with cognitive frailty.
The protocol aims to evaluate the immediate effects (sixteen weeks after weekly supervised sessions, i.e. on the 16th week) and the mid-term effects (three months when the intervention has been completed, i.e. on the 28th week). Hypotheses include that the treatment group will show greater improvements in global cognitive functions compared to the control group at Week 16, as well as greater enhancements in physical and cognitive performance than the control group at Week 16 and 28.
Overall, this research addresses the research gap in interventions for older adults with cognitive frailty, aiming to provide an evidence-based approach to improve their cognitive and physical health outcomes. The anticipated findings might have significant implications for the development of early-stage interventions and clinical practice that can enhance the quality of life for this vulnerable population.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
盲法说明
The researchers who perform the outcome assessment and analysis will be blinded to the group allocation of participants.
入排标准
- 年龄范围
- 60 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged 60 and above;
- •Community-dwelling, as defined by living at home and not having stayed in a long-term care facility in the last 12 months as reported by the participants;
- •Able to walk independently or with a stick;
- •A cutoff value of = 0 in the Physical Activity Readiness Questionnaire for Everyone (PAR-Q+) indicates the participants' physical stability;
- •A cutoff score of = 0.5 in the Clinical Dementia Rating indicates participants with Mild Cognitive Impairment (MCI);
- •A cutoff score of ≥1 on the FRAIL Scale indicates participants with physical frailty;
排除标准
- •Is suffering from any critical medical or psychiatric illness;
- •Has an uncorrectable visual and/or hearing impairment that hinders the participation;
- •Is having the MCI or physical frailty only;
- •Is participating in other trials;
- •Chronic use of corticosteroids, immunosuppressive drugs, androgen-, estrogen-, or progestin-containing compounds
- •Taking psychotropic, antiarrhythmic, or hypnotic medications
- •Advised by healthcare professionals (e.g., physicians or physiotherapists) not to participate in moderate-to-vigorous exercises.
- •Older adults with special conditions or increased risk of injuries that require substantial adjustment in exercise regime, including those with COPD, renal disease, cancer, etc.
研究组 & 干预措施
Music-with-Movement Simultaneous Cognitive-Motor Dual-Task Training (MM-SDTT) group
Participants in the treatment group will undergo a 16-week MM-SDTT program, which includes once-weekly center-based sessions and twice-weekly home-based sessions. Center-based sessions will be supervised by an interventionist with a physical fitness background, while participants will have home-based sessions using provided training videos.
干预措施: music-based cognitive-motor dual-task training/exercise (Behavioral)
Social Control Group
Participants in the social control group will have social chatting weekly for 45 minutes over 16 weeks, to control the potential social effect of the MM-SDTT on cognitive functions. Remedial MM-SDTT will be delivered to the social control group after the data collection is completed.
干预措施: Social Gatherings (Behavioral)
结局指标
主要结局
Montreal Cognitive Assessment
时间窗: Change from baseline to 28 weeks after programme
The Montreal Cognitive Assessment (MoCA) is a test of global cognitive functions. MoCA consists of 8 domains, including attention and concentration, executive functions, memory, language, visuoconstructional skills, conceptual thinking, calculations, and orientation. The scores range from 0 to 30, with higher scores indicating better cognitive functions.
次要结局
- Frontal Assessment Battery(Change from baseline to 28 weeks after programme)
- Fuld Object Memory Evaluation(Change from baseline to 28 weeks after programme)
- Modified Fuld Verbal Fluency Test(Change from baseline to 28 weeks after programme)
- Social Participation Quesionnaire(Change from baseline to 28 weeks after programme)
- Subjective Happiness Scale(Change from baseline to 28 weeks after programme)
- DeJong Gierveld Loneliness Scale(Change from baseline to 28 weeks after programme)
- Edmonton Frail Scale(Change from baseline to 28 weeks after programme)
- Six-minute Walk Test(Change from baseline to 28 weeks after programme)
- Timed Up and Go Test(Change from baseline to 28 weeks after programme)
- Handgrip Strength(Change from baseline to 28 weeks after programme)
研究者
Dr. Justina Liu Yat Wa
Principal Investigator
The Hong Kong Polytechnic University