Assessment of Colonic Epithelial Integrity With Mucosal Impedance
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- Mucosal Impedance Values
研究概览
简要总结
In this study, the investigators propose to use mucosal impedance (MI), a minimally invasive technology, to detect mucosal damage (i.e. barrier dysfunction) based on mucosal conductivity changes in the colonic epithelium.
详细描述
The intestinal epithelium functions to separate luminal contents from the interstitium. Increased intestinal permeability can represent compromise of the epithelium's integrity. Prior research has demonstrated that defects in intestinal barrier function are associated with inflammatory bowel disease (IBD) and increased intestinal permeability can be important in the maintenance of remission in IBD patients. There is currently not a convenient way to measure colonic epithelial barrier function in real time which could provide clinically relevant information .
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Men and women over the age of 18 with a diagnosis of IBD (Ulcerative Colitis or Crohn's Disease)
- •Men and women undergoing screening colonoscopy (typical age would be 50 or greater but there are exceptions)
排除标准
- •Age less than 18 years old
- •Patients unable to give informed consent
- •Patients with history of colonic surgeries
- •Patients with history of colonic motility disorder
结局指标
主要结局
Mucosal Impedance Values
时间窗: 15 minutes
compare the mucosal impedance values between subjects with IBD and controls
次要结局
- Difference in Inflamed and Normal Mucosa(15 minutes)
研究者
Yash Amit Choksi
Principal Investigator
Vanderbilt University Medical Center