NCT04185272招募中不适用
Role of Butyrophilins in Colon Cancers Aggressiveness Evaluation
Institut Paoli-Calmettes1 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2020年6月30日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- evaluation of BTNL3, BTNL8 and BTNL9 expression by transcriptomics and immunohistochemistry
研究概览
简要总结
quantification of BTNL molecules in colon cancer in order to determinate if their could be used as a prognostic marquer
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient is older than 18 years old,
- •Signed participation consent,
- •Non-metastatic colon cancer immediately resectable or metastatic and liver synchronous for which it was decided a combined colic and liver surgery (metastatic patient at the outset) in multidisciplinary consultation meeting.
- •Performance Status (PS) 0 or 1
- •affiliated to the social security or beneficiary
排除标准
- •Rectal cancer, colon cancer recurrence
- •Emergency of colon cancer Surgery
- •History of inflammatory disease of the digestive tract (Crohn's disease or ulcerative colitis)
- •Patient who received neoadjuvant therapy other than chemotherapy
- •Patient treated with immune-suppressors or long-course corticosteroids <12 months
- •Pregnant women or likely to be pregnant (without effective contraception) or breastfeeding,
- •Person in urgent situation, person under legal protection measure, or unable to express his / her consent,
- •Impossibility of submitting to the medical examination of the test for geographical, social or psychological reasons
研究组 & 干预措施
non-metastatic colon cancer
Experimental
干预措施: analysis of BTN and BTNL status (Biological)
metastatic colon cancer
Experimental
干预措施: analysis of BTN and BTNL status (Biological)
结局指标
主要结局
evaluation of BTNL3, BTNL8 and BTNL9 expression by transcriptomics and immunohistochemistry
时间窗: 8 years
healthy and cancerous colon ad metastasis (if applicable) will be analysed by
次要结局
未报告次要终点
研究者
研究点 (1)
Loading locations...
相似试验
已完成
不适用
Mode of Action of Butyrate in the Human ColonIrritable Bowel Syndrome (IBS)HealthyNCT05249023Örebro University, Sweden37
招募中
不适用
Molecular diagnositcs of colon cancerKCT0002703MD Healthcare350
招募中
不适用
Gastrointestinal Biomarkers in Tissue and Biological Fluid Samples From Colorectal Cancer PatientsPrecancerous ConditionColorectal CancerPancreatic CancerGastric CancerEsophageal CancerNCT00899626Vanderbilt University Medical Center5,000
已完成
不适用
Blood and Tissue Sample Collection for Future Colon Cancer Biomarker Studies in Patients Undergoing ColonoscopyHealth Status UnknownColorectal CancerNCT00897403Vanderbilt University6,446
已完成
不适用
Evaluation of biomarkers in the colonic mucosa using biopsy specimesuspected colorectal diseasesJPRN-UMIN000014378Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine100