Preventive and Personalized Medicine (2021-2023)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 700
- 试验地点
- 2
- 主要终点
- number of SNPs associated with breast cancer
研究概览
简要总结
This is a GWAS study that aims to identify possible candidate genes associate to breast cancer by exploring single nucleotide polymorphism (SNP) in a group of breast cancer, in the Kazakh population. The investigators hypothesize that the careful phenotyping of the subject sand matching with increase the power to find SNP significantly associate with breast cancer
详细描述
A genome-wide association study (GWAS) is an approach used in genetics research to associate specific genetic variations with particular diseases. The method involves scanning the genomes from many different people and looking for genetic markers that can be used to predict the presence of a disease. Once such genetic markers are identified, they can be used to understand how genes contribute to the disease and develop better prevention and treatment strategies.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Persons with a histologically confirmed diagnosis of breast cancer.
- •The age of patients is from 18 to 60 years;
- •Persons of Kazakh nationality, whose paternal and maternal grandparents are Kazakhs.
- •Persons who are able and willing to provide written informed consent;
- •Persons capable and willing to comply with the research protocol;
排除标准
- •Persons under 18 and over 60 years old;
- •Persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent;
- •Pregnant or lactating women;
- •Tuberculosis of any localization in the active phase and in history;
- •Severe and decompensated diseases of the liver and kidneys, cardiovascular system;
- •Severe and decompensated course of endocrine diseases;
- •Lack of histological verification of breast tumor
结局指标
主要结局
number of SNPs associated with breast cancer
时间窗: 1 year
Using GWAS to identify candidate genes associate with breast cancer
次要结局
未报告次要终点
研究者
Ildar Fakhradiyev
Head of the Laboratory of Experimental Medicine
Asfendiyarov Kazakh National Medical University