Screening for Barrett’s esophagus: accuracy of exhaled breath analysis using an electronic nose device - a validation study

Radboudumc0 个研究点目标入组 980 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

暂无简介。

•Aged 18 years or older
•-Undergoing a clinically indicated (surveillance) endoscopy
•-Able to give signed informed consent
•1.Patients with known BE (defined as =1 cm of columnar mucosa with histopathologic confirmation of intestinal metaplasia without dysplasia)
•2.Individuals with GERD symptoms without BE (GERDQ-score =8 or the endoscopic presence of reflux esophagitis)
•3.‘Healthy’ controls without BE or GERD

•-Patients with a history of any type of malignancy (not including basal-cell skin cancer (BCC) and squamous-cell skin cancer (SCC))
•-Prior surgical esophageal or gastric resection or prior ablative therapy
•-Patients who are unable to perform breathing maneuver needed for Aeonose-analysis of exhaled breath
•Withdrawal criteria after initial study inclusion:
•Patients can be withdrawn from the study if:
•-Incomplete upper endoscopy
•-Active H. Pylori infection
•-BE segment <1cm or no intestinal metaplasia in the esophagus
•-Intestinal metaplasia in the stomach

发起方