Evaluation of the Role of IgE Responses to Der p 1 and Der p 2 in Chinese House Dust Mite-Allergic Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Der p 2 Serum IgE
研究概览
简要总结
One hundred patients were enrolled, based on sensitization and doctor-diagnosed allergy to HDM. Questionnaires were administered to document demographic and clinical characteristics. Serum IgE reactivity toDermatophagoides pteronyssinus (Dp) extract, Der p 1, Der p 2 and Der p 10 was measured by ImmunoCAP.
详细描述
Background: The role of specific IgE (sIgE) against Der p 1and Der p 2 in Chinese patients with house dust mite (HDM)allergy has not yet been well investigated.Methods: One hundred patients were enrolled, based on sensitization and doctor-diagnosed allergy to HDM. Questionnaires were administered to document demographic and clinical characteristics. Serum IgE reactivity toDermatophagoides pteronyssinus (Dp) extract, Der p 1, Der p 2 and Der p 10 was measured by ImmunoCAP.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 3 Years 至 60 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •HDM-allergic patients reporting allergic rhinitis, conjunctivitis, asthma and/or atopic dermatitis and who had never undergone immunotherapy, were enrolled if they were sensitized to Dp as judged by ImmunoCAP ( ≥ 1 kU/l) and/or skin reaction index (SRI)by skin-prick test (SPT, a wheal diameter ≥ 0.5 mm).
排除标准
- •Patients who refused to participate in the study.
结局指标
主要结局
Der p 2 Serum IgE
时间窗: 1 year
Prevalence of Der p 2 Serum IgE in HDM-Allergic Patients
Demographic Characteristics
时间窗: 1 year
Describe the patient's basic information in detail, including age, gender, family history, etc
Factors associated with specific IgE against Der p 1
时间窗: 1 year
Study the patient's basic information and identify factors that are clearly associated with specific IgE against Der p 1
Der p 1 Serum IgE
时间窗: 1 year
Prevalence of Der p 1 Serum IgE in HDM-Allergic Patients
the Number of Affected Organs
时间窗: 1 year
Association of Specific IgE Titers with the Number of Affected Organs
Dp, Der p 1 and Der p 2
时间窗: 1 year
Relationship between Serum IgE Levels of Dp, Der p 1 and Der p 2
Factors associated with specific IgE against Der p 2
时间窗: 1 year
Study the patient's basic information and identify factors that are clearly associated with specific IgE against Der p 2
次要结局
未报告次要终点