The Significances of Atropin Administration for the GLP-1 Potentiation of Glucose Induced Insulin Secretion and the Cephalic Insulin Response
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- insulin secretion
研究概览
简要总结
The aim of this study is to investigate the role of transmission of vagal cholinerg for the GLP-1 potentiation of the glucose stimulated insulin secretion and the cephalic insulin response by using atropin administration.
The hypothesis is that a great deal of the effects of GLP-1 is mediated via the nervous system and for this reason the investigators will research individuals with an intact nervous supply with and without atropin administration.
详细描述
GLP-1 is a importent enterogastron and incretin hormone. Rapid degradation of GLP-1 by dipeptidyl peptidase 4 (DPP-4) suggests that GLP-1 may act locally (through vagal afferents) before being degraded. We aimed to clarify the role of vagal innervation on the incretin effect.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •age between 18 and 45 years
- •normal fasting plasma glucose
- •normal hemoglobin
- •informed consent
排除标准
- •diabetes mellitus
- •body mass index above 30
- •inflamatoric bowel disease
- •intestinal surgery
- •serum creatinine above 250 microM
- •ALAT above to times normal value
- •treatment with medicine wich cannot be paused for 12 hours
- •contraindication for treatment with atropin
研究组 & 干预措施
Atropin
Atropin
干预措施: Atropine (Drug)
Placebo
Saline
干预措施: Placebo (Drug)
结局指标
主要结局
insulin secretion
时间窗: tree hours
The insulin secretion during lightly elevated blood glucose during GLP-1 infusions with and without atropin administration is evaluated. Also the insulin secretion during lightly elevated blood glucose during a sham-feeding with and without atropin administration is evaluated.
次要结局
- Plasma glucose(33 timepoints within tree hours)
- Plasma PP(20 time points within tree hours)
- Plasma glucagon(18 timepoints within tree hours)
- Plasma GLP-2(18 time points within tree hours)
- Plasma GIP(18 timepoints within tree hours)
- Plasma GLP-1(18 time points within tree hours)
研究者
Jonatan I Bagger
MD
University Hospital, Gentofte, Copenhagen