Study on the Myocardial Protective Effect of RIPC in Patients Undergoing OPCABG
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- ICU staying time
研究概览
简要总结
The purpose of the study was to verify the myocardial protective effect of RIPC in patients undergoing OPCABG.
详细描述
66 patients scheduled for OPCABG are randomly assigned to a RIPC group(n=33) or a control group(n=33). In the RIPC group, 4 cycles of 5-min ischemia(using a blood pressure cuff inflated to 40mmHg over the patient's basic blood pressure) and 5-min repercussion are done on an upper limb before skin incision. Patients in the control group wear the same cuff on an upper limb but no pressure is applied. Anesthetic and surgical techniques are standardized during the trial. Serum inflammatory cytokines and cardiac injury markers will be measured before and after surgery. Internal mammary artery and saphenous vein tissues will be collected during the surgery to assess hypoxia-inducible factor (Hif)-1a and other signalling proteins.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •serious changes in several coronary arteries that need to receive OPCABG
- •NHYA II-III
- •ASA II-III
排除标准
- •LVEF< 35%
- •acute myocardial infarction
- •multiple organ dysfunction
研究组 & 干预措施
RIPC
4 cycles of 5-min ischemia(using a blood pressure cuff inflated to 40mmHg over the patient's basic blood pressure) and 5-min repercussion are done on an upper limb.
干预措施: RIPC (Other)
control
patient in control group using a blood pressure cuff on an upper limb without inflating
干预措施: RIPC (Other)
结局指标
主要结局
ICU staying time
时间窗: average of 1 year
the time patients spend in ICU after surgery
次要结局
未报告次要终点