Remote Ischemic Preconditioning Induces Myocardial RISK Signaling Pathway in Patients Undergoing Valvular Heart Surgery

Phase 4

Completed

• Conditions: Patients With Elective Aortic Valve Replacement
• Interventions: Procedure: Control group; Procedure: Remote ischemic preconditioning at left upper arm

• Registration Number: NCT01946087
• Lead Sponsor: Yonsei University

Brief Summary

The aim of this study is to investigate whether RIPC protects the heart against ischemia reperfusion injury on the concentrically hypertrophied myocardium

Detailed Description

Not available

Basic Information
|
Recruitment & Eligibility
|
Study & Design
|
Trial Locations

Study Timeline

• Study Start: 2013-06
• Study First Submitted: 2013-09-04
• Study First Submitted QC: 2013-09-16
• Study First Posted: 2013-09-19
• Primary Completion: 2016-04
• Study Completion: 2016-04
• Status Verified: 2016-11
• Last Update Submitted: 2016-11-19
• Last Update Posted: 2016-11-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 79

Inclusion Criteria

• Patients aged ≥20 years with severe degenerative AS presenting concentric remodeling of the LV, who were scheduled for AVR

Read More

Exclusion Criteria

• diabetes mellitus,
• coronary stenosis ≥70%,
• renal failure (serum creatinine > 2.0 mg/dL),
• upper arm peripheral vascular disease,
• LV ejection fraction <50%

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control group	Control group	-
RIPC group	Remote ischemic preconditioning at left upper arm	-

Primary Outcome Measures

Name	Time	Method
Serum levels of CK-MB and Tn-T	24-hour after surgery

Secondary Outcome Measures

Name	Time	Method
Myocardial activation of protective signaling pathway	After taking off CPB

Trial Locations

Locations (1)

Yonsei University College of Medicine; 🇰🇷 Seoul, Korea, Republic of