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临床试验/NCT07554105
NCT07554105招募中不适用

Effect of Transcranial Random Noise Stimulation on the Performance in Language Tasks

Adrian Guggisberg1 个研究点 分布在 1 个国家目标入组 90 人开始时间: 2026年3月17日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
招募中
入组人数
90
试验地点
1
主要终点
Composite score

研究概览

简要总结

Language is an essential part of daily life, enabling us to communicate, understand others, read, and learn. Certain brain injuries can disrupt these abilities, and current treatments do not always lead to a full recovery. To improve future therapeutic approaches, it is necessary to better understand how the brain processes language and how its activity can be modulated.

This study aims to evaluate the effects of a non-invasive brain stimulation technique called transcranial random noise stimulation. This method involves applying a very weak electrical current to the scalp to modulate the activity of brain regions involved in language. It is commonly used in research and is considered safe when administered in accordance with current guidelines.

Healthy adult volunteers will participate in this study. Each participant will take part in two sessions spaced about a week apart. During one session, active stimulation will be used, and during the other, placebo stimulation will be used. Placebo stimulation resembles the actual stimulation but has no active effect. Neither the participants nor the researchers will know which type of stimulation is being used during each session.

During the sessions, participants will perform various language tasks, and their brain activity will be recorded using an electroencephalogram (EEG), a painless method.

This study does not provide any direct benefit to participants. The risks are low and limited to temporary sensations, such as a tingling sensation on the scalp. The results will provide a better understanding of how the brain processes language and could eventually contribute to the development of new rehabilitation approaches.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Basic Science
盲法
Single (Participant)

入排标准

年龄范围
18 Years 至 90 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Age: 18-35 years or 60-90 years
  • Native French speakers
  • Right handed
  • Willing and able to provide informed consent
  • Normal or corrected-to-normal vision and hearing

排除标准

  • History of neurological or psychiatric disease
  • Regular consumption of benzodiazepines, neuroleptics, or psychoactive drugs
  • Major language deficit, developmental language disorder, arthropathies and other mechanical language impairments
  • Inability to understand or follow study procedures
  • Contraindications to brain stimulation, such as
  • History of epilepsy or severe migraine
  • Pacemaker or other active implants
  • Metallic objects in the head
  • Skull breach such as craniotomy
  • Pregnancy

研究组 & 干预措施

Younger adults

Other

age 15-35 years

干预措施: transcranial random noise stimulation (Device)

Younger adults

Other

age 15-35 years

干预措施: sham stimulation (Device)

Elderly adults

Other

age 60-90 years

干预措施: transcranial random noise stimulation (Device)

Elderly adults

Other

age 60-90 years

干预措施: sham stimulation (Device)

结局指标

主要结局

Composite score

时间窗: Periprocedural

composite behavioural score reflecting overall language performance across four language domains (phonological, semantic, morphosyntactic, and reading)

次要结局

  • Phonological processing(Periprocedural)
  • Semantic processing(Periprocedural)
  • Morphosyntactic processing(Periprocedural)
  • Reading speed(Periprocedural)
  • Sustained attention(Periprocedural)

研究者

申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Adrian Guggisberg

Head of Neurorehabilitation

University Hospital, Geneva

研究点 (1)

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