EUCTR2012-002553-38-ES进行中（未招募）不适用
Mesenchymal stem cell based therapy for the treatment of osteogenesis imperfecta - TERCELOI
Itziar Astigarraga Aguirre0 个研究点开始时间: 2013年4月9日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •1.-Patient age: older than 6 months and younger than 12 years old.
- •2.-Patients with molecular confirmation of mutation in either COL1A1 or COL1A2 genes associated with severe deforming OI (type III).
- •3.-Patiens with HLA identical (that shared at least 5/6 antigens) siblings willing to donate bone marrow-MSCs.
- •4.-All patients that fulfil the inclusion criteria regardless of whether or not they are undergoing biphosphonate treatment
- •5.-Patients whose parents or the legal guardians are willing to sign the consent forms to participate in this clinical trial.
- •Are the trial subjects under 18? yes
- •Number of subjects for this age range: 3
- •F.1.2 Adults (18-64 years) no
- •F.1.2.1 Number of subjects for this age range
- •F.1.3 Elderly (>=65 years) no
- •F.1.3.1 Number of subjects for this age range
排除标准
- •1.-Patient age: older than 12 years old
- •2.-Patients lacking confirmation of mutation in either COL1A1 or COL1A2 genes associated with severe deforming OI (type III).
- •3.-Other pathological subtypes of OI.
- •4.-Patiens lacking of HLA identical (that shared at least 5/6 antigens) siblings willing to donate bone marrow-MSCs.
- •5.-Immunodeficiencies and any other malignancies
- •6.-Participation in other clinical trial
- •7.-Any medical or psychiatric condition that in the researcher?s opinion could affect the patient´s ability to complete the trial or hamper the participation in the trial.
- •8.-Patients whose parents or the legal guardians do not sign the consent forms
研究者
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