NCT02630212Unknown不适用
The Relationship Between ALDH2 and Aortic Dissection
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 400
- 试验地点
- 1
- 主要终点
- Number of patients with different ALDH2 genotype
研究概览
简要总结
The purpose of this study is to evaluate the impact of ALDH2 Glu504Lys polymorphism on aortic dissection.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Chinese Han people diagnosed with aortic dissection in Qilu Hospital
排除标准
- •Aortic dissection based on trauma, connective tissue diseases and pregnancy
- •Patients with tumor
- •Patients with no written consensus
结局指标
主要结局
Number of patients with different ALDH2 genotype
时间窗: 1-30 days after samples collected
DNA was extracted from venous blood;genomic DNA underwent PCR amplification; finally, PCR products were purified and directly sequenced by Invitrogen Corp or Biosune Corp.Then ALDH2 genotype was distinguished depend on a G-to-A missense mutation on exon 12 of ALDH2 gene.
次要结局
- Concentration of inflammatory factors in blood and aortic specimen(1-30 days after samples collected)
- ALDH2 activity(1-30 days after samples collected)
研究者
研究点 (1)
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