A Case-Control Study of Esophageal Squamous Cell Carcinoma in Lilongwe, Malawi
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 648
- 试验地点
- 2
- 主要终点
- Esophageal squamous cell carcinoma
研究概览
简要总结
Background:
Esophageal cancer is a common cause of cancer deaths. Most cases of this cancer are esophageal squamous cell carcinoma (ESCC). Many of these cases come from two parts of the world with high-risk. One of these is in East Africa and include the country of Malawi. Researchers want to learn what factors explain the high risk there so we can understand better what causes this cancer in people everywhere.
Objective:
To learn more about causes and outcomes of esophageal squamous cell carcinoma using Malawi because of the large number of cases in that country.
Eligibility:
Adults at least 18 years old who have ESCC and live in a certain region of Malawi
Adults in the same age group and location who do not have ESCC
Design:
Participants will be screened at a hospital in Malawi.
Participants will have a 1-hour interview. They will answer questions about:
Demographics (age, ethnicity, education)
Place of residence
Medical history and family medical history
Drug, alcohol, and tobacco use
Hot beverage consumption
Indoor air pollution
Occupation
Food habits
Farming
Gastrointestinal health
Participants will have their teeth and fingernails examined.
Participants will be asked to give samples of blood, urine, saliva, toenails, and for the cancer cases, a small piece of their tumor.
Participants will have 4 phone calls a year for 2 years to ask about their health....
详细描述
Background: Esophageal cancer causes an estimated 400,000 deaths per year and ranks as the sixth leading cause of cancer death worldwide, just after breast cancer. Esophageal squamous cell carcinoma (ESCC) accounts for 89% of all esophageal cancer cases worldwide and many of the cases originate in two high risk regions, one in Asia and the other in Africa.
Smoking tobacco and heavy alcohol consumption do not explain the incidence rates in the high-risk regions. It is therefore important to consider a wide range of etiologic factors to explain the high rates of cancer in these populations.
Malawi has the highest incidence rates of ESCC in Africa. Our previous studies in Kenya and preliminary studies in Malawi point to a number of potential ESCC risk factors.
Objectives: Our study aims to enhance our understanding of the causes and outcomes for ESCC in Malawi
Eligibility: All suspected ESCC cases will be eligible for enrollment.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Esophageal squamous cell carcinoma
时间窗: At diagnosis
Pathology confirmed from endoscopic biopsy
次要结局
未报告次要终点