Assessment of Muscle Metabolism Using Magnetic Resonance Spectroscopy With Clinical Strengthening in Parkinson's Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 19
- 试验地点
- 1
- 主要终点
- Muscle metabolic properties (P-31 MRS)
研究概览
简要总结
This investigation assesses the impact of a strengthening program on muscle metabolism in the gastrocnemius muscle (GM) and is an essential step in the establishment of future clinical intervention for the GM in people with Parkinson's disease (with healthy peers as the control group). The participants will be provided with a progressive GM strengthening program while monitoring muscle metabolism and functional changes before and after intervention.
详细描述
This is a repeated measures study with a total of 20 participants (15 individuals with varying PD severity and 5 age matched controls). Strength, functional ability, and metabolic properties (MRS) of the GM will be measured on participants before and after a 4 week progressive strengthening program for the GM. The program is designed to utilize high volume exercise to account for unique properties of the GM (2 sets of heel raises to fatigue, 3 times a week). Loading will be individualized and progressed based on participant strength. There will be contact for accountability/direction on exercise progression. Demographic data including sex, age, medications, and years since disease onset will be collected.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 50 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •50-80 years of age, males and females, individuals with and without PD
- •Hoehn and Yahr stages 1- 4 (if diagnosed with PD)
- •Bilateral Heal Raise - minimum of 10 repetitions
排除标准
- •Unable to walk for >5 minutes at a time with or without an assistive device
- •Any comorbidity limiting exercise
结局指标
主要结局
Muscle metabolic properties (P-31 MRS)
时间窗: Day 1 (baseline) and 4 weeks (post exercise program)
A non-invasive measure of metabolites and their dynamics in resting and activated human muscles to explores how well muscle handles its ATP energy demands.
次要结局
- Gastrocnemius strength(Day 1 (baseline) and 4 weeks (post exercise program))
研究者
Staci Shearin
Associate Professor
University of Texas Southwestern Medical Center