Investigation of Possible Sarcopenia and/or the Presence of Sarcopenia in Patients With Primary Sjögren's Syndrome and Its Effect on Functional Status
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- muscle strength
研究概览
简要总结
The aim of this study is to evaluate the frequency of probable sarcopenia and sarcopenia in patients with primary Sjögren syndrome and to investigate the effects of sarcopenia on functional status, muscle strength, and quality of life. Adult patients diagnosed with primary Sjögren syndrome will be included in the study. Muscle strength, muscle mass, physical performance, and functional status will be assessed using various evaluation methods
详细描述
Primary Sjögren syndrome is a chronic autoimmune inflammatory disease that may affect the musculoskeletal system. Sarcopenia is characterized by decreased muscle mass and muscle strength and may lead to impaired physical performance and functional capacity.
In this cross-sectional study, the presence of probable sarcopenia and sarcopenia in adult patients with primary Sjögren syndrome will be evaluated. Demographic characteristics, disease duration, and clinical findings of the participants will be recorded. Muscle strength will be assessed using handgrip strength testing, and physical performance will be evaluated using functional performance tests. In addition functional status scales will be administered.
The study aims to determine the effects of sarcopenia on functional status and quality of life in patients with primary Sjögren syndrome.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Voluntarily
- •Women over the age of 18
- •Women diagnosed with primary Sjögren's syndrome
排除标准
- •Those with cognitive impairment
- •Those with other rheumatic diseases
- •Uncontrolled chronic disease(diabetes mellitus, hypertension, hypothyroidism, hyperthyroidism)
- •Those who have difficulty walking on their own
- •Arthritis present in the dominant hand joints
- •Central and peripheral nervous system findings
- •Myositis and mechanical pain
- •Individuals receiving treatment for hyperlipidemia
研究组 & 干预措施
primary sjögren syndrome group
Participants' muscle strength, muscle mass, and physical performance were examined.
干预措施: dexa, hand grip strength, myostatin, follistatin (Diagnostic Test)
Control group
Participants' muscle strength, muscle mass, and physical performance were examined.
干预措施: dexa, hand grip strength, myostatin, follistatin (Diagnostic Test)
结局指标
主要结局
muscle strength
时间窗: 12 month
Muscle strength will be assessed using hand-held dynamometry. Measurements will be recorded in kilograms-force (kgf) and compared between primary Sjögren syndrome patients and healthy controls.
muscle mass
时间窗: 12 months
Muscle mass will be assessed using DEXA. Results will be compared between groups.
functional status
时间窗: 12 months
Functional status will be evaluated using validated functional assessment scales. Scores will be compared between primary Sjögren syndrome patients and healthy controls.
次要结局
- myostatin(12 months)
- follistatin(12 months)