Comparative study of intubating conditions at 60 seconds between high dose rocuronium and combination of low dose rocuronium with magnesium sulphate and ketamine in adults.
试验速览
- 阶段
- 2/3 期
- 状态
- 尚未招募
- 入组人数
- 68
- 试验地点
- 1
- 主要终点
- To evaluate if combination of low dose rocuronium 0.6 mg/kg IV with magnesium sulphate 30 mg/kg IV and ketamine 1 mg/kg IV provides better intubating conditions compared to high dose rocuronium 0.9 mg/kg IV alone,at 60 seconds.
研究概览
简要总结
Rocuronium is a non depolarizing muscle relaxant used for rapid sequence induction in conditions where succinylcholine is contraindicated. In this randomized control study we would be looking forward to find out if combination of low dose rocuronium 0.6 mg/kg IV with magnesium sulphate 30 mg/kg IV and ketamine 1 mg/kg IV provides better intubating conditions at 60 seconds compared to high dose rocuronium 0.9 mg/kg IV alone. We would also be looking at the hemodynamic response between both the groups.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Open Label
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •65 years ASA PS 1-2 BMI 18.
- •24.9 kg/m2 Mallampati grade 1-2 Elective surgery under general anaesthesia requiring intubation.
排除标准
- •Neuromuscualr disease Renal insufficiency Hepatic insufficiency Allergy to study drugs Breast feeding or pregnancy Anticipated difficult airway Heart block Recent histort of URTI.
结局指标
主要结局
To evaluate if combination of low dose rocuronium 0.6 mg/kg IV with magnesium sulphate 30 mg/kg IV and ketamine 1 mg/kg IV provides better intubating conditions compared to high dose rocuronium 0.9 mg/kg IV alone,at 60 seconds.
时间窗: At 60 seconds after induction.
次要结局
- To compare hemodynamic response mean arterial pressure and heart rate between the two groups(At baseline, after induction, after intubation, 3 minutes and 6 minutes thereafter.)