BLEACHING EFFECT OF STRAWBERRY EXTRACT VERSUS HYDROGEN PEROXIDE IN PATIENTS WITH EXRINSIC STAINING A RANDOMIZED CLINICAL TRIAL
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 40
- 主要终点
- Bleaching effect of strawberry extract versus Hydrogen peroxide.
研究概览
简要总结
with limited evidence based information in literature about using Strawberry extract for teeth bleaching in patients with extrinsic staining , it is beneficial to evaluate this new material using a randomized controlled clinical trial to test the null hypothesis that this extract will have the same effect as Hydrogen peroxide regarding the bleaching effect and hypersensitivity.
详细描述
The whitening effect of strawberry is due to the presence of malic acid, which acts as a natural astringent to remove surface discoloration. The ellagic acid content in strawberry is ranging from 0.43 to 4.64 mg/g dry weight. The more amount of ellagic acid will produce more potential OH clusters as a powerful oxidizer thus make the more effective bleaching process. Ellagic acid releases the OH and H radicals which will react with the tooth enamel organic molecules and disrupt the electron conjugation, as well as changing the energy absorption in the tooth enamel organic molecules to form smaller organic molecules with a lighter color. Ellagic acid has an OH cluster, not COOH cluster like any other acids. The electronegativity of the OH group will be easier to break and react with the organic molecules of tooth enamel.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participant inclusion criteria:
- •At least 18 years old.
- •Good general and oral health.
- •six present maxillary anterior teeth.
- •Tooth inclusion criteria:
- •yellowing of teeth due to age.
- •stains due to coffee or tea.
- •light tetracycline stain.
排除标准
- •participant exclusion criteria:
- •patients undergoing radiotherapy or chemotherapy.
- •Pregnant females or breast feeders.
- •Bruxism and patients who reported tooth sensitivity.
- •Tooth exclusion criteria:
- •Hypoplastic enamel.
- •carious lesion.
- •sensitive recession area or sensitive tooth.
- •Amalgam staining.
- •Non vital tooth.
- •Discolration due to pulp trauma or necrosis.
- •presence of non carious cervical lesion.
研究组 & 干预措施
patients with extrinsic staining will be treated with strawberry extract.
干预措施: strawberry extract. (Other)
patients with extrinsic staining will be treated with Hydrogen peroxide bleaching agent.
干预措施: strawberry extract. (Other)
结局指标
主要结局
Bleaching effect of strawberry extract versus Hydrogen peroxide.
时间窗: immediately , one week and one month after application.
objective assessment for the bleaching effect by spectrophotometer.
次要结局
- post operative sensitivity.(immediately after bleaching agent removal , 24 hours after application.)
研究者
Randa Khaled Mostafa
principle investigator
Cairo University