The Application of Contrast-enhanced Ultrasound in Acute Kidney Injury in Intensive Care Unit
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 44
- 试验地点
- 1
- 主要终点
- Serum creatinine values and/or urine output
研究概览
简要总结
The goal of this study is to quantitatively assess renal microcirculation changes by contrast-enhanced ultrasound and to obtain systemic hemodynamic information by ultrasound Doppler at the same time, to analyze the relationship between renal microcirculation changes and systemic hemodynamic changes, and to explore its predictive value in renal function recovery in patients with critical acute kidney injury. The main questions it aims to answer are:
- To explore the quantitative parameters of contrast-enhanced ultrasound which can reflect the changes of renal microcirculation.
- To explore the relationship between renal microcirculation and systemic hemodynamics.
- To explore the value of renal microflow changes quantitatively evaluated by contrast-enhanced ultrasound in predicting renal function recovery.
详细描述
Quantitative analysis of cortical perfusion by contrast-enhanced ultrasound； Echocardiography； Quantitative results of renal artery and vein spectrum
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age >18 years old;
- •AKI was diagnosed < 24 hours after first admission to intensive care unit (ICU) and the expected length of stay in ICU ≥48 hours;
- •Meet Kidney Disease Improving Global Outcomes (KDIGO) 2012 diagnostic criteria for acute kidney injury;
- •Contrast-enhanced ultrasound was performed within 24 hours after diagnosis of acute kidney injury (AKI).
排除标准
- •Known severe chronic kidney disease (CKD≥ stage 4) or undergoing hemodialysis treatment;
- •Kidney transplantation or renal malignancy;
- •Terminal stage of malignant tumor;
- •Pregnancy;
- •Renal artery stenosis or renal vein thrombosis;
- •Allergy to contrast agent SonoVue(BraccoSpA, Milan, Italy) or its components, or the presence of severe cardiopulmonary insufficiency (e.g., right-to-left shunt heart disease or pulmonary systolic blood pressure >90mmHg).
结局指标
主要结局
Serum creatinine values and/or urine output
时间窗: Through study completion, an average of 7 days
Complete recovery (defined as a return to normal serum creatinine and urine volume) and reversal of acute kidney injury (AKI) (more than 50% improvement in serum creatinine and/or urine volume from baseline), non-recovery included persistent AKI(no significant improvement or further increase in serum creatinine and/or urine volume, the need for dialysis, or death.)
次要结局
未报告次要终点
研究者
Cui Ligang
Chief Physician
Peking University Third Hospital