NL-OMON35274已完成不适用
Periodontitis and ACPA positive Arthralgia*s; a link by protein citrullination - Periodontitis and ACPA positive Arthralgia*s
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 200
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Patients who are ACPA and or RF positive and who have arthralgia*s, aged > 18 years.
排除标准
- •Fullfilling ACR criteria for RA.
- •Exclusion criteria (according to the SENIEUR protocol 1984)
- •1. Infection other than periodontitis.
- •2. Inflammation other than periodontitis (RA, Crohn*s disease, collagen-vascular diseases).
- •3. Malignancy, past or present.
- •4. Other conditions which influence the immune system: diabetes, active thyroid disease, myocardial infarction, stroke or recanalisation of the femoral arteries for claudication <6 months prior to the study.
- •5. Pregnancy including a 6-months post-partum period as well as breastfeeding.
- •6. Malnutrition.
- •7. Alcoholism and drug abuse.
- •8. Pharmacological interference: prescribed medication for the treatment of a defined disease, use of corticosteroids >10mg/day, antibiotic use during 3 months prior to the study.
- •9. Periodontal treatment prior to the study.
- •10. Edentulism.
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