Hypoxia and Aerobic Exercise Interactions in Age-related Metabolic Muscle Dysfunction
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 29
- 试验地点
- 2
- 主要终点
- Insulin sensitivity
研究概览
简要总结
Ageing is the primary risk factor for most chronic diseases including type 2 diabetes mellitus. Sarcopenia and muscular mitochondrial dysfunction with aging are crucial mechanisms leading to decreased exercise tolerance and worsened insulin sensitivity. Thus, metabolic disease and frailty, which limits physical mobility as well as quality of life, share common cellular mechanisms.
The investigators will test the hypothesis that a combination of normobaric hypoxia and exercise training elicits a synergistic effect on age-associated metabolic skeletal muscle dysfunction and the investigators will address the molecular mechanisms. In a randomized clinical study, the investigators will compare normoxic and hypoxic training conditions in elderly subjects. Outcome measures will focus on whole body insulin sensitivity and mitochondrial responses in skeletal muscle before and after the 8-week training intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 55 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •55 to 75 years of age
- •body mass index: 20 - 35 kg/m2
- •weight stable during last 6 months before screening (weight change < 2% body weight)
- •HOMA-index of insulin resistance ≥ 2 to 4 units
排除标准
- •more than 1 hour of scheduled exercise training per week
- •known diagnosis of type 2 diabetes or measured HbA1c > 6,5%
- •known drug or alcohol abuse
- •any contraindication to perform exercise training
- •acute or chronic infections
- •increased bleeding risk by history, INR > 1,3, use of anticoagulants
研究组 & 干预措施
Hypoxic Exercise
Supervised, progressive aerobic exercise for 8 weeks under hypoxic conditions
干预措施: Hypoxic exercise (Other)
Normoxic exercise
Supervised, progressive aerobic exercise for 8 weeks under normoxic conditions
干预措施: Normoxic Exercise (Other)
结局指标
主要结局
Insulin sensitivity
时间窗: At baseline and after 8 weeks
Insulin sensitivity is assessed via the hyperinsulinemic euglycemic glucose clamp and expressed as the glucose infusion rate (GIR) in ml
次要结局
- Maximum oxygen uptake(At baseline and after 8 weeks)
- Mitochondrial number(At baseline and after 8 weeks)
- Body fat and body fat free mass(At baseline and after 8 weeks)
- Fat and carbohydrate oxidation during exercise(At baseline and after 8 weeks)
- Health related quality of life(At baseline and after 8 weeks)