The Effects of Exercise on Cognition and Brain Health in Older Adults at Risk for Type 2 Diabetes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Trail Making Test
研究概览
简要总结
Older adults with type 2 diabetes experience neurocognitive decline and are at higher risk for developing dementia. Consequently, older adults at-risk for developing type 2 diabetes (i.e., those who are overweight and/or prediabetic) are at higher risk for neurocognitive decline, and intervening at this point may prevent or delay the onset of such decline. One promising lifestyle intervention that has been shown to improve cognitive function and brain health in other populations is resistance exercise. We previously conducted a 6-month resistance training randomized controlled trial (RCT) pilot study that showed a large scale trial would be viable and feasible. Consequently, we would like to explore resistance exercise as a lifestyle intervention to improve cognition and brain structure in older adults at risk for diabetes.
详细描述
The effects of exercise on cognition and brain structure in older adults at risk for type 2 diabetes: A 3T MRI study
Objectives/research questions:
In this study the research questions included:
- Does twice-weekly resistance training impact cognitive function compared to balance-and-tone exercises in older adults at risk for diabetes?
- Can resistance training modify brain structure and volume in various brain structures, particularly the hippocampus, compared with balance-and-tone training (control) in older adults at risk for diabetes?
Hypotheses:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Double (Participant, Outcomes Assessor)
盲法说明
Both participants and accessors will be blinded to group allocation
入排标准
- 年龄范围
- 60 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Community-dwelling
- •Aged 60-80 years
- •"At-risk" for diabetes, where they have one of the following: i) blood glucose level of 6.1-7 mmol/L, ii) body mass index > 25, or iii) score > 21 on the CANRISK diabetes questionnaire
- •Score > 24/30 on MMSE
- •Score > 6/8 on the IADL scale
- •Visual acuity of at least 20/40, with or without corrective lenses
- •Speak and understand English fluently
- •Complete the PAR-Q
- •Obtain physician's clearance to start a supervised exercise program
排除标准
- •Current medical condition for which exercise is contraindicated
- •Participated regularly in resistance or aerobic training in the last 6 months
- •Diagnosed with neurodegenerative disease (including dementia, Alzheimer's disease, or Parkinson's disease)
- •Experienced a vascular incident (e.g., stroke, myocardial infarction)
- •Diagnosed with a psychiatric condition
- •Untreated depression and scored 5 or less on the Geriatric Depression Scale
- •Currently on hormone replacement therapy
- •Clinically significant peripheral neuropathy or severe musculoskeletal or joint disease
- •Currently taking psychotropic medications
- •Cannot blood draw
结局指标
主要结局
Trail Making Test
时间窗: 5 minutes
Used to assess executive function in the areas of visual attention (Part A) and set-shifting (the ability to shift attention between one task and another; Part B). The time to complete this test is recorded in seconds.
次要结局
- Triglyceride levels(30 minutes)
- Inflammatory markers(30 minutes)
- Trail Unique-Non-Matching-Location (TUNL) Task(20 minutes)
- Brain-derived neurotrophic factor levels(1 hour)
- Paired Associative Learning (PAL) Touchscreen Task(20 minutes)
- Progressive Ratio (PR) Touchscreen Task(20 minutes)
- Insulin-like growth factor levels(1 hour)
- One repetition maximum(10-15 minutes)
- Stroop Test(5-10 minutes)
- Digit Span Test(5-10 minutes)
- Glycated hemoglobin A1c (HbA1C)(5-10 minutes)
- Height(5 minutes)
- Six-minute walk test(6 minutes)
- Short Physical Performance Battery (SPPB) - Task 2(5 minutes)
- Alzheimer's Disease Assessment Scale Cognitive Subscale 11(15 minutes)
- Fasting plasma glucose(5-10 minutes)
- Weight(5 minutes)
- Short Physical Performance Battery (SPPB) - Task 1(5 minutes)
- Short Physical Performance Battery (SPPB) - Task 3(5 minutes)
- Timed Up and Go Test(5-10 minutes)
研究者
Lindsay Nagamatsu
Assistant Professor
Western University, Canada