Effects of Aging and Aerobic Exercise Training on Brain Glucose Metabolism

Not Applicable

Completed

• Conditions: Dementia
• Interventions: Behavioral: High intensity aerobic training; Behavioral: Sedentary Control

• Registration Number: NCT01738568
• Lead Sponsor: Mayo Clinic

Brief Summary

Aging is associated with a loss of brain function and conditions such as dementia and Alzheimer's disease. It is likely that decreased brain metabolism is contributing to the progression of age related degenerative diseases. Aerobic exercise training can increase brain volumes and is associated with decreased risk for degenerative brain conditions. However, little is know about the changes that occur to brain metabolism with aerobic training and aging.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-10
• Study First Submitted: 2012-11-27
• Study First Submitted QC: 2012-11-29
• Study First Posted: 2012-11-30
• Primary Completion: 2015-02-12
• Study Completion: 2015-02-12
• Status Verified: 2021-08
• Last Update Submitted: 2021-08-24
• Last Update Posted: 2021-08-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 27

Inclusion Criteria

• Age 18-30 years or 65-80 years

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Exclusion Criteria

• Body mass index (BMI) >31 kg/m2
• Smoking
• Pregnancy
• Participation in structured exercise (>2 times per week for 30 minutes or longer)
• Cardiovascular, metabolic (type 2 diabetes, fasting plasma glucose at or above 110 mg/dL and untreated hypo- or hyperthyroidism) or renal disease
• Orthopedic problems that would keep them from being able to ride an exercise bicycle, lift weights or do a combination of these exercise
• Medications that are known to impact on mitochondrial function: Corticosteroids, opiates, benzodiazepines, tricyclic antidepressants, beta blockers, sulfonylureas, insulin, anticoagulants, barbiturates, insulin sensitizers, fibrates (PPAR gamma agonist)
• Claustrophobia

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Exercise	Sedentary Control	Aerobic exercise
Exercise	High intensity aerobic training	Aerobic exercise

Primary Outcome Measures

Name	Time	Method
Change in Brain Glucose Uptake	12 weeks	The investigators will assess brain glucose uptake using positron emission tomography at baseline and following 12-weeks of either aerobic exercise training or sedentary control period.

Trial Locations

Locations (1)

Mayo Clinic in Rochester; 🇺🇸 Rochester, Minnesota, United States