Effect of Aging and Aerobic Exercise Training on Brain Glucose Metabolism

Mayo Clinic1 site in 1 country27 target enrollmentOctober 2012

ConditionsDementia

Overview

Phase: N/A
Intervention: Not specified
Conditions: Dementia
Sponsor: Mayo Clinic
Enrollment: 27
Locations: 1
Primary Endpoint: Change in Brain Glucose Uptake
Status: Completed
Last Updated: 4 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Aging is associated with a loss of brain function and conditions such as dementia and Alzheimer's disease. It is likely that decreased brain metabolism is contributing to the progression of age related degenerative diseases. Aerobic exercise training can increase brain volumes and is associated with decreased risk for degenerative brain conditions. However, little is know about the changes that occur to brain metabolism with aerobic training and aging.

Registry

clinicaltrials.gov

Start Date

October 2012

End Date

February 12, 2015

Last Updated

4 years ago

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

Mayo Clinic

Responsible Party

Principal Investigator

Val Lowe

Mayo Clinic

Eligibility Criteria

Inclusion Criteria

•Age 18-30 years or 65-80 years

Exclusion Criteria

•Body mass index (BMI) \>31 kg/m2
•Pregnancy
•Participation in structured exercise (\>2 times per week for 30 minutes or longer)
•Cardiovascular, metabolic (type 2 diabetes, fasting plasma glucose at or above 110 mg/dL and untreated hypo- or hyperthyroidism) or renal disease
•Orthopedic problems that would keep them from being able to ride an exercise bicycle, lift weights or do a combination of these exercise
•Medications that are known to impact on mitochondrial function: Corticosteroids, opiates, benzodiazepines, tricyclic antidepressants, beta blockers, sulfonylureas, insulin, anticoagulants, barbiturates, insulin sensitizers, fibrates (PPAR gamma agonist)
•Claustrophobia

Outcomes

Primary Outcomes

Change in Brain Glucose Uptake

Time Frame: 12 weeks

The investigators will assess brain glucose uptake using positron emission tomography at baseline and following 12-weeks of either aerobic exercise training or sedentary control period.