The Effect of Water Intake on Glucose Regulation: A Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 主要终点
- metabolic clearance rate for insulin
研究概览
简要总结
There is a growing body of evidence suggesting low water intake and elevated levels of the hormone vasopressin exacerbate glucose regulation. This project will examine the physiological mechanism by which low water intake impairs glucose homeostasis.
In the current proposal we aim to: 1) quantify the degree of glucose impairment as a response to elevated vasopressin due to low water intake and 2) identify the physiological mechanism by which elevated vasopressin, as a response to low water intake, impairs glucose regulation
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 30 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI 27.5-35
排除标准
- •BMI <27.5 or >35
- •high physical activity
- •impaired liver or kidney function
- •cardiovascular disease
- •weight change of more than 3 kg in the past month
- •pregnancy
- •previous surgery on digestive tract (except appendectomy)
- •fluid balance will be exclusionary such as
- •serotonin re-uptake inhibitors.
结局指标
主要结局
metabolic clearance rate for insulin
时间窗: 220-240 min & 340-360 min of the protocol
metabolic clearance rate for insulin during the euglycemic \& Hyperglycemic clamp
amount of glucose metabolized M
时间窗: 220-240 min & 340-360 min of the protocol
amount of glucose metabolized during the euglycemic \& Hyperglycemic clamp
quantity of glucose metabolized per unit plasma insulin concentration
时间窗: 220-240 min & 340-360 min of the protocol
quantity of glucose metabolized per unit plasma insulin concentration during the euglycemic \& Hyperglycemic clamp
Rate of glucose appearance & disappearance
时间窗: 220-240 min & 340-360 min of the protocol
Rate of glucose appearance \& disappearance during the euglycemic \& Hyperglycemic clamp
次要结局
- glucagon(0 min, 240 min & 360 min of the protocol)
- Plasma copeptin(0 min, 240 min & 360 min of the protocol)
- Cortisol(0 min, 240 min & 360 min of the protocol)
研究者
Stavros Kavouras
Professor of Nutrition
Arizona State University