Effect of Desmopressin on Platelet Function in CKD Patients on Antiplatelet Agent Who Need Emergent Temporary Catheter Insertion for Hemodialysis
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 25
- 试验地点
- 1
- 主要终点
- collagen-epinephrine closure time
研究概览
简要总结
Prolonged Collagen/Epinephrine - closure time (CEPI-CT) indicates platelet dysfunction in CKD patients taking antiplatelet agent. The synthetic vasopressin derivative, Desmopressin (DDAVP) shortens the prolonged bleeding time and improves platelet dysfunction measured by in vitro closure time: CEPI-CT in uremic patients. Desmopressin also antagonizes the in vitro platelet dysfunction induced by GPIIb/IIIa inhibitors, clopidogrel and aspirin. The investigators designed a prospective study to evaluate the effect of desmopressin on platelet function, as measured by in vitro collagen/epinephrine - closure time, in uremic patients who were taking antiplatelet drugs.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adult uremic patients with one or more antiplatelet medication,
- •prolonged collagen/epinephrine (CEPI) closure time,
- •need for emergent hemodialysis and
- •subsequent catheter insertion
排除标准
- •acute coronary syndrome,
- •hemophilia, and nephrogenic diabetes insipidus,
- •allergy against desmopressin
研究组 & 干预措施
Desmopressin
Twenty five patients with chronic kidney disease and who were taking antiplatelet agents and needed an emergent catheter insertion for hemodialysis
干预措施: Desmopressin administration (Drug)
结局指标
主要结局
collagen-epinephrine closure time
时间窗: 1 hour
In vitro closure time (CT), measured using a platelet function analyzer (PFA)-100, is a relatively new tool for investigation of primary hemostasis. This system has been shown to be efficacious in evaluating abnormalities of primary hemostasis.
次要结局
- Bleeding after procedure(1-4 hr after procedure)
研究者
Soon Bae Kim, M.D., PhD.
Professor of Medicine
University of Ulsan