Effects of Exercise Behavior Modification on Plasma Adiponectin and Insulin Resistance in High Risk Subjects of Diabetes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 216
- 试验地点
- 1
- 主要终点
- Plasma adiponectin level in μg/ml
研究概览
简要总结
Investigators hypothesized home-based exercise intervention was beneficial to those who have had diabetic risk factor for type 2 diabetes mellitus
详细描述
This randomized clinical trial was designed to investigate whether a home-based exercise could improve adiponectin levels, exercise behavior and metabolic risk factors (insulin resistance, metabolic components and physical fitness) in subjects with at least a diabetic risk factor for type 2 diabetes mellitus. Participants were randomly allocated to either a control group or a home-based exercise group. All participants were evaluated for outcome measures at baseline, and at 3-month 6-month and 9-month follow-up after engaging in the intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •At least one of the following criteria as following: BMI >=24 kg/m*m, hypertension, dyslipidemia, fist-degree relatives of parents with type 2 diabetes, impaired glucose tolerance, gestational diabetes and delivering a babt weighing >=4.0 kg
- •Ability of understanding Chinese or Taiwanese
排除标准
- •Receiving treatment with insulin or oral hypoglycemic agents
- •Any other serious illness that prohibit them to undertake fitness evaluation
研究组 & 干预措施
Lifestyle counseling
To promote participants' exercise behaviors with individualized home-based exercise program was designed based on the Health Belief Model and Transtheoretical Model
干预措施: Physical activity promoting intervention (Behavioral)
Control
Received oral instruction and written general education information without individualized exercise program
干预措施: General instruction and education (Behavioral)
结局指标
主要结局
Plasma adiponectin level in μg/ml
时间窗: Nine months after the start of the intervention
Fasting blood samples were centrifuged to obtain plasma and then immediately stored at -20℃. Plasma adiponectin levels were then determined through enzyme-linked immunoassay (ELISA).
Exercise behavior
时间窗: Nine months after the start of the intervention
1. Exercise self-efficacy: Measured by exercise self-efficacy questionnaire in score 2. Physical activity: Meausred by 7-day recall questionnaire in kcal/kg/day
次要结局
- Insulin resistance(Three, 6 and 9 months after the start of the intervention)
- Metabolic components(Three, 6 and 9 months after the start of the intervention)
- Physical fitness(Three, 6 and 9 months after the start of the intervention)
- Dietary intake(Three, 6 and 9 months after the start of the intervention)
- Plasma adiponectin level in μg/ml(Three and 6 months after the start of the intervention)
- Exercise behavior(Three and 6 months after the start of the intervention)