A controlled trial of ovulation stimulation with intrauterine insemination (IUI) versus in vitro fertilisation (IVF)

The Royal Women's Hospital (Australia)0 个研究点目标入组 600 人开始时间: 2004年3月17日最近更新: 2015年1月13日

试验速览

暂无简介。

•1. Infertility of 12 months or longer duration
•2. Primary or secondary infertility
•3. New patient or patient returning after an interval of longer than 1 year
•4. Female age 18-42, male age 18-60 years
•5. Detailed male and female partner clinical evaluation, investigation of semen quality and objective evidence of ovulation and tubal patency

•1. Coital disorders, including infrequent or mistimed coitus (<1 per 3 days during mid cycle)
•2. Tubal obstruction (one or both on sonohysterogram, laparoscopy or laparotomy) or known ligation
•3. Male infertility requiring intracytoplasmic sperm injection (ICSI): average sperm concentration less than 2 million/ml, progressive motility less than 25%, or abnormal morphology greater than 95% in two or more semen tests performed within the previous 12 months in the Royal Women's Hospital andrology laboratory, sperm autoimmunity (Immunobead Test [IBT] IgG or IgA antibodies on >50% of motile sperm together with blocked sperm mucus penetration: < 3 cm at 1h in the capillary tube test), reduced sperm zona pellucida (ZP) binding (ratio <0.3) or disordered ZP-induced acrosome reaction (ZPIAR) (<16%) confirmed in 2 sperm ZP interaction tests, or less than 2 million motile sperm for IUI assessed by trial sperm preparation
•4. Untreated ovulatory disorders (patients treated for 6 ovulatory cycles without a pregnancy can enter the trial)
•5. Ovarian endometrioma (patients with treated or untreated mild endometriosis can enter the trial)
•6. Miscellaneous (for example: a contraindication to multiple pregnancy)
•7. Currently treated patients

发起方

The Royal Women's Hospital (Australia)