ISRCTN28780587
已完成
不适用
A controlled trial of ovulation stimulation with intrauterine insemination (IUI) versus in vitro fertilisation (IVF)
The Royal Women's Hospital (Australia)0 个研究点目标入组 600 人2004年3月17日
概览
- 阶段
- 不适用
- 干预措施
- 未指定
- 疾病 / 适应症
- 未指定
- 发起方
- The Royal Women's Hospital (Australia)
- 入组人数
- 600
- 状态
- 已完成
- 最后更新
- 11年前
概览
简要总结
暂无简介。
研究者
入排标准
入选标准
- •1\. Infertility of 12 months or longer duration
- •2\. Primary or secondary infertility
- •3\. New patient or patient returning after an interval of longer than 1 year
- •4\. Female age 18\-42, male age 18\-60 years
- •5\. Detailed male and female partner clinical evaluation, investigation of semen quality and objective evidence of ovulation and tubal patency
排除标准
- •1\. Coital disorders, including infrequent or mistimed coitus (\<1 per 3 days during mid cycle)
- •2\. Tubal obstruction (one or both on sonohysterogram, laparoscopy or laparotomy) or known ligation
- •3\. Male infertility requiring intracytoplasmic sperm injection (ICSI): average sperm concentration less than 2 million/ml, progressive motility less than 25%, or abnormal morphology greater than 95% in two or more semen tests performed within the previous 12 months in the Royal Women's Hospital andrology laboratory, sperm autoimmunity (Immunobead Test \[IBT] IgG or IgA antibodies on \>50% of motile sperm together with blocked sperm mucus penetration: \< 3 cm at 1h in the capillary tube test), reduced sperm zona pellucida (ZP) binding (ratio \<0\.3\) or disordered ZP\-induced acrosome reaction (ZPIAR) (\<16%) confirmed in 2 sperm ZP interaction tests, or less than 2 million motile sperm for IUI assessed by trial sperm preparation
- •4\. Untreated ovulatory disorders (patients treated for 6 ovulatory cycles without a pregnancy can enter the trial)
- •5\. Ovarian endometrioma (patients with treated or untreated mild endometriosis can enter the trial)
- •6\. Miscellaneous (for example: a contraindication to multiple pregnancy)
- •7\. Currently treated patients
结局指标
主要结局
未指定
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