Accelerated Biological and Phenotypic Aging in Hematopoietic Cell Transplant Survivors: Social Support as a Protective Factor
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 110
- 试验地点
- 2
- 主要终点
- The number of participants with gene expression of cellular senescence marker p16.
研究概览
简要总结
This project aims to elucidate the important protective elements of social relationships and identify concrete, modifiable behavioral factors that contribute to biological and phenotypic aging in hematopoietic cell transplantation (HCT) survivors and can be used to develop biologically informed interventions to improve quality of life and prolong the healthspan of individuals with accelerated aging.
详细描述
PRIMARY OBJECTIVES:
I. Examine associations between social support, strain, and isolation and phenotypic aging over the 1-year recovery period.
II. Examine associations between social support, strain, and isolation and biological aging over the 1-year recovery period.
III. Test biological aging as a mediator linking social processes and phenotypic aging.
EXPLORATORY OBJECTIVE:
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Aged 18 years and older who are competent to give their informed consent.
- •Ability to read, speak, and understand English.
- •Received a hematopoietic cell transplant within the previous 100 days.
排除标准
- •Less then Aged 18 years and older who are competent to give their informed consent.
- •Cannot read, speak, and understand English.
- •Has not received a hematopoietic cell transplant within the previous 100 days.
研究组 & 干预措施
Supportive care (EAR, questionnaires, biospecimen collection)
Participants will complete comprehensive assessments of social processes at 100 days and 1 year after HCT that combine reports of social support, strain, and isolation with a naturalistic observation tool, the Electronically Activated Recorder (EAR), which captures ambient sound bites to assess social interactions in survivors' daily lives. At each time point, participants will also provide reports of symptoms to characterize phenotypic aging, including cognitive, physical, and functional complaints, and blood samples to assess biological aging, including cellular senescence, DNA damage, SASP, and cellular stress using genome wide RNA sequencing. Relevant clinical information that could influence biological aging will also be collected from patients' medical records to consider as covariates.
干预措施: Biospecimen Collection (Procedure)
Supportive care (EAR, questionnaires, biospecimen collection)
Participants will complete comprehensive assessments of social processes at 100 days and 1 year after HCT that combine reports of social support, strain, and isolation with a naturalistic observation tool, the Electronically Activated Recorder (EAR), which captures ambient sound bites to assess social interactions in survivors' daily lives. At each time point, participants will also provide reports of symptoms to characterize phenotypic aging, including cognitive, physical, and functional complaints, and blood samples to assess biological aging, including cellular senescence, DNA damage, SASP, and cellular stress using genome wide RNA sequencing. Relevant clinical information that could influence biological aging will also be collected from patients' medical records to consider as covariates.
干预措施: Electronic Health Record Review (Other)
Supportive care (EAR, questionnaires, biospecimen collection)
Participants will complete comprehensive assessments of social processes at 100 days and 1 year after HCT that combine reports of social support, strain, and isolation with a naturalistic observation tool, the Electronically Activated Recorder (EAR), which captures ambient sound bites to assess social interactions in survivors' daily lives. At each time point, participants will also provide reports of symptoms to characterize phenotypic aging, including cognitive, physical, and functional complaints, and blood samples to assess biological aging, including cellular senescence, DNA damage, SASP, and cellular stress using genome wide RNA sequencing. Relevant clinical information that could influence biological aging will also be collected from patients' medical records to consider as covariates.
干预措施: Questionnaire Administration (Other)
结局指标
主要结局
The number of participants with gene expression of cellular senescence marker p16.
时间窗: Day 100 and 1 year post-transplant
This will be measured by mRNA/gene expression.
次要结局
未报告次要终点
研究者
Kelly E Rentscher, PhD
Principal Investigator
Medical College of Wisconsin