Eosinophilic esophagitis-Indian scenario.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 101
- 试验地点
- 1
- 主要终点
- To determine the prevalence of eosinophilic esophagitis using aa standardized biopsy
研究概览
简要总结
After obtaining written informed consent and checking for exclusion criteria, patients with symptoms suggestive of GERD or esophageal dysfunction will be recruited for endoscopy.
Information regarding relevant history, physical examination, demographic and laboratory parameters will be entered in a preformatted data sheet.
All patients will undergo upper endoscopy. 4 biopsies from each quadrant will be taken 14cms and 4cms above the esophagogastric junctions regardless of macroscopic appearance using standard biopsy forceps.
Biopsies will be stored in 10% formalin for pathological examination.
The average eosinophil count in high power magnification will be taken for diagnosis.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 80.00 Year(s)（—）
- 性别
- All
入选标准
- •All patients above 18 years of age.
- •Symptoms suggestive of eosinophilic esophagitis like Heartburn, chronic reflux, dysphagia, food impaction and esophageal chest pain.
- •Any endoscopic evidence of eosinophilic esophagitis which include linear furrows, pinpoint exudates, feline rings, stricture, fixed rings, or esophagitis.
排除标准
- •Cardio-respiratory, renal comorbidities precluding diagnostic endoscopy.
- •Patients with history of drug-induced esophagitis.
- •Crohn’s disease Esophageal malignancy Intake of PPI within last 4 weeks.
结局指标
主要结局
To determine the prevalence of eosinophilic esophagitis using aa standardized biopsy
时间窗: 6 months
protocol.
时间窗: 6 months
次要结局
- To see for prevalence of eosinophilic esophagitis in GERD, Predictive factors for(eosinophilic esophagitis like atopy.)
研究者
Dr Ganesh Bhat
Manipal Academy of Higher Education