NCT02311075已完成不适用
Determination of the Mechanisms Involved in Conduit Artery Endothelial Dysfunction in Type 2 Diabetes
University Hospital, Rouen2 个研究点 分布在 1 个国家目标入组 48 人开始时间: 2014年12月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 48
- 试验地点
- 2
- 主要终点
- Change from Baseline in EET concentration during endothelial stimulation
研究概览
简要总结
Endothelial dysfunction of conduit arteries plays an important role in the development of cardiovascular complications associated with type 2 diabetes. In order to propose targeted therapeutic approaches, this study aim to determine the mechanisms involved in endothelial dysfunction of conduit arteries in these patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Type 2 diabetic patients or control subjects or healthy volunteers
排除标准
- •Macroangiopathy
- •Insulin treatment
- •Chronic kidney disease (eGFR<60 ml/min/m²)
- •Hyperlipidemia (total cholesterol>2.5 g/l)
- •Smoking habit > 5 cigarettes/day
- •Pregnancy
结局指标
主要结局
Change from Baseline in EET concentration during endothelial stimulation
时间窗: 30 min from the beginning of hand skin heating
次要结局
- Change from Baseline in NO concentration during endothelial stimulation(30 min from the beginning of hand skin heating)
- Change from Baseline in ET-1 concentration during endothelial stimulation(30 min from the beginning of hand skin heating)
- Change from Baseline in ROS concentration during endothelial stimulation(30 min from the beginning of hand skin heating)
研究者
研究点 (2)
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