The Impact of Platelet Count, Platelet Mass Index and Platelet Function Evaluated by Platelet Function Analyzer (PFA-100) on Spontaneous Ductal Closure in Preterm Infants
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- spontaneous ductal closure
研究概览
简要总结
Although thrombocytopenia has been reported as a risk factor for patent ductus arterioses, there is lack of data on the function of platelets in ductal closure. Information on functions of platelets in ductal closure may change the known model for ductus arterioses and may affect the treatment modalities.
详细描述
Patent ductus arterioses is a common problem which involves both pulmonary and cardiac outcomes in preterm infants. Although thrombocytopenia has been reported as a risk factor for patent ductus arterioses, there is lack of data on the function of platelets in ductal closure.
The investigators aim to investigate the relation between thrombocytopenia and platelet functions in pathogenesis of spontaneous ductal closure. The investigators hypothesize that Information on functions of platelets in ductal closure may change the known model for ductus arterioses and may affect the treatment modalities.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 2 Days 至 7 Days（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •gestational age lower than 30 weeks and birth weight lower than 1500 g
- •obtained informed consent
排除标准
- •any received medical treatment in first 2 days of life
- •death in first 2 days
- •patients who received any thrombocyte or fresh frozen plasma suspensions
- •any known genetic thrombocyte disorder in the family
结局指标
主要结局
spontaneous ductal closure
时间窗: 8 weeks
ductal closure confirmed by echocardiography on postnatal 2-3 days
次要结局
- need for treatment(8 weeks)
研究者
Omer Erdeve
Associate Professor
Ankara University