Identification of Novel Targets for Regulation of Adipose Tissue Mass
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 62
- 试验地点
- 1
- 主要终点
- number of adipocytes and preadipocytes under weight loss
研究概览
简要总结
The aim of this study is to understand the metabolic changes occurring in fat tissue both during controlled weight loss that lead to the improvement of type 2 diabetes and other obesity associated metabolic disorders. The novelty of the study is the analysis of preadipocytes, a poorly characterized subfraction of the adipose tissue, which provides adipocyte precursors and thereby strongly influences adipose tissue mass changes. Knowledge of pathways involved in controlling adipose tissue composition will help to design novel intervention strategies for the treatment of obesity associated metabolic disorders such as type 2 diabetes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Participants of the OPTIFAST52 program
- •BMI > 30 kg/m2
排除标准
- •Rejection of informed consent by the participant
研究组 & 干预措施
Optifast
Patients included take part at a weight reduction program over one year.
干预措施: Optifast (Dietary Supplement)
结局指标
主要结局
number of adipocytes and preadipocytes under weight loss
时间窗: three years
次要结局
- metabolic function of adipocytes and preadipocytes under weight loss(three years)
研究者
Gottfried Rudofsky
Oberarzt
Heidelberg University