Vibration Mediated Dilation and Flow Mediated Dilation in Human Circulatory System
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 2
- 主要终点
- Brachial Artery Diameter
研究概览
简要总结
Application of vibration has been previously shown to affect tissue perfusion and utilized in different branches of medicine. Little is known about the acute impact of vibration application on peripheral artery hemodynamics. In this study, investigators intend to assess:
- vibration induced hemodynamic changes in brachial artery in non-diabetic patients and compare the characteristics of these alterations with flow mediated dilation mediated changes in same cohort.
- compare the characteristics of vibration mediated hemodynamic alterations in diabetic and non-diabetic subgroups.
详细描述
Background and Rationale:
Vibration application has been previously shown to affect tissue perfusion and utilized in different branches of medicine. However, previous studies have mainly focused on the impact of vibration on skin perfusion or vibration with active muscle contractions, therefore couldn't truly demonstrate acute impact of local vibration application on peripheral arteries. In addition to that, as a population that is prone to develop vascular problems, it is not known whether diabetic patients have comparable response to vibration application with non-diabetic population.
Objectives:
In this study, investigators aim to demonstrate and compare hemodynamic alterations in brachial artery with paired measurements pre- and post- vibration application and compare the characteristics of these changes with those of flow-mediated dilation in a non-diabetic cohort. Additionally, differences and similarities in vascular hemodynamic response to vibration in diabetic and non-diabetic subgroups are intended to be elucidated.
Methods:
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Sinus Rhythm in ECG
- •Ejection Fraction > %35
- •Informed Consent
排除标准
- •Unstabile angina
- •Certain or suspected subclavian artery or brachial artery atherosclerotic disease (assessed with USG)
- •Heart failure ( New York Heart Association III - IV)
- •Atrial fibrillation or frequent extrasystoles in ECG.
结局指标
主要结局
Brachial Artery Diameter
时间窗: Up to 10 minutes after vibration application initiation
vessel diameter in millimeters
Brachial Artery Mean Flow Velocity
时间窗: Up to 10 minutes after vibration application initiation
Mean flow velocity ( cm/sec) measured with Doppler
次要结局
未报告次要终点
研究者
Dr. Murat Sezer
Professor, MD
Istanbul University