Ischemic Preconditioning as an Intervention to Improve Stroke Rehabilitation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Change in Knee Extensor Strength
研究概览
简要总结
This study will be the first study to use ischemic preconditioning (IPC) as an intervention to improve stroke rehabilitation. IPC is a well studied, well tolerated intervention which has been shown to improve regional blood flow, motor neuron excitability and muscle function in multiple patient groups and in young, healthy subjects. Because IPC targets three physiological systems which are all affected by stroke, we hypothesize that repeated bouts of IPC during the first days to months following stroke (when the majority of recovery occurs) will make traditional rehabilitation strategies more effective.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •be between the ages of 40-80
- •able to give informed consent.
- •be < 6 months post diagnosis of unilateral cortical stroke and
- •have residual leg paresis.
排除标准
- •chronic low back or hip pain
- •substance abuse
- •head trauma with loss of conciousness in last 6 months
- •neurodegenerative disorder
- •participant taking any medication or supplement that adversely interacts with nitroglycerin (exclusion from nitro administration only, applies to outpatients only)
- •participant has a known allergy to nitroglycerin (exclusion from nitro administration only, applies to outpatients only)
- •resting systolic blood pressure < 90mmHg (exclusion from nitro administration only, applies to outpatients only)
- •any condition where knee extension contractions are contraindicated
- •people who are unable to follow multi step commands.
- •pregnancy (DXA scan exclusion only)
- •history of major psychiatric disorder
- •participant has had a myocardial infarction in the last year
- •participant has stage II hypertension (BP>160/100)
- •participant is unable to contract knee muscles
- •participant is unable to sit upright for 2 hours
- •participant has a resting heart rate >100 beats per minute
- •history of multiple strokes
结局指标
主要结局
Change in Knee Extensor Strength
时间窗: Admission into study and within 3 days of Discharge from Froedtert Hospital
次要结局
- Change in Walking Speed(Admission into study and within 3 days of Discharge from Froedtert Hospital)
研究者
Matthew J. Durand
Assistant Professor
Medical College of Wisconsin