Association Between Extracranial Carotid & Intracranial Arterial Stenosis in Ischemic Stroke Patients: Predictors & Outcome
试验速览
- 阶段
- 不适用
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- National Institutes of Health Stroke Scale
研究概览
简要总结
The aim of the work is to; elucidate how the presence of carotid stenosis influence the pattern of stroke and also how it interact with other risk factors for stroke. Also identify predictors of intracranial stenosis and outcome in patients with carotid stenosis with or without intracranial stenosis.
详细描述
Patients:
Ischemic stroke patients admitted to Neurology department in Mansoura University hospital (MUH) will be studied
The patients will be grouped as follow:
- Patients with significant carotid stenosis without intracranial stenosis.
- Patients with carotid and intracranial stenosis.
- Patients with lone intracranial stenosis.
- patients with no significant carotid or intracranial stenosis.
Methods:
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Carotid TIA (transient ischemic attack) it should, however, be focal and usually motor-sensory to implicate the carotid artery system or ischemic stroke involving carotid territory.
- •Asymptomatic patients with carotid stenosis or anterior circulation stenosis discovered accidentally during investigations for further risk factors.
排除标准
- •Major functional impairment (Modified Rankin Scale >/= 3)
- •Significant cognitive impairment.
- •Contraindication to acetylsalicylic or dual antiplatelet.
- •Renal dysfunction precluding safe contrast medium administration.
- •pregnancy or refusal.
- •Intracranial aneurysm or AVM.
- •Intra cerebral hemorrhage or hemorrhagic infarction.
结局指标
主要结局
National Institutes of Health Stroke Scale
时间窗: 24 hours
The National Institutes of Health Stroke Scale is a tool used by healthcare providers to objectively quantify the impairment caused by a stroke. The NIHSS is composed of 11 items, each of which scores a specific ability between a 0 and 4. For each item, a score of 0 typically indicates normal function in that specific ability, while a higher score is indicative of some level of impairment. The individual scores from each item are summed in order to calculate a patient's total NIHSS score. The maximum possible score is 42, with the minimum score being a 0. The higher score indicate poor outcome.
次要结局
- Beck's Depression Inventory(24hours)
- The modified Rankin Scale(24 hours)
研究者
Ahmed Esmael
Assistant Prof of Neurology
Mansoura University Hospital