Effect Of Aerobic Versus Resistance Exercises On Clinical Markers Of Hyperandrogenism In PCOS: A Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Modified Ferriman Gallwey score (mFG)
研究概览
简要总结
Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder among women of reproductive age characterized by hyperandrogenism ovulatory dysfunction and polycystic ovaries. Symptoms such as hirsutism acne menstrual irregularities and psychological distress significantly impact quality of life. Insulin resistance and hormonal imbalances play a central role in its pathophysiology. Lifestyle modification particularly exercise is considered a first line treatment. While both aerobic exercise and high intensity resistance training (HIRT) improve metabolic and reproductive outcomes their specific effects on the psychological well being of women with PCOS remain less understood. This study aims to explore and compare the impact of these two exercise modalities on the clinical markers of Hyperandrogenism in PCOS.
Objective To compare the change in Modified Ferriman Gallwey (mFG) score from baseline to 6 weeks between the Aerobic (Group A) and Resistance (Group B) groups.
To compare change in acne lesion count from baseline to 6 weeks.
Methodology A Randomized Controlled Trial will be conducted to evaluate the effects of exercise modalities on women with PCOS. A total of 70 women aged 18 to 40 years diagnosed with PCOS based on Rotterdam or NIH criteria and showing clinical signs of hyperandrogenism (hirsutism with mFG score greater than equal to 8 and or active acne) were randomly assigned using the SNOSE method. The study spanned 6 weeks. Exclusion criteria included recent use of anti androgen medications pregnancy or lactation and other endocrine disorders affecting androgen levels. This study seeks to compare the effects of a 6 week aerobic exercise program versus resistance exercise program.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18.00 Year(s) 至 40.00 Year(s)（—）
- 性别
- Female
入选标准
- •Female aged 18 years to 40 years Women already diagnosed with PCOS by either Rotterdam or NIH Criteria Clinical Evidence Of Hyperandrogenism Hirsutism(mFG score greater than or equal to 8) and or Active Acne(Clinically Countable Lesions).
排除标准
- •Current use (within past 3 months) of systemic anti-androgen medications Pregnant planning pregnancy during study or breastfeeding Known endocrine disorders other than PCOS that affect androgens (eg Cushings syndrome androgen secreting tumor).
结局指标
主要结局
Modified Ferriman Gallwey score (mFG)
时间窗: Baseline (0 week) | Mid point (3 week) | End point (6 week)
Acne lesion count assessment
时间窗: Baseline (0 week) | Mid point (3 week) | End point (6 week)
次要结局
未报告次要终点
研究者
Dr SUMEDHA MANE
KAHER Institute Of Physiotherapy