临床试验/NCT01452048

NCT01452048已完成不适用

Relationship Between Systemic Fatty Acid Availability and Insulin Sensitivity

University of Michigan1 个研究点分布在 1 个国家目标入组 38 人开始时间: 2011年9月最近更新: 2022年3月21日

适应症

试验速览

阶段: 不适用
状态: 已完成
发起方: University of Michigan
入组人数: 38
试验地点: 1
主要终点: Insulin Sensitivity

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

The investigators specific aim is to compare the relationship between systemic fatty acid availability and insulin sensitivity in a relatively homogenous population of obese adults. The investigators anticipate 1) greater systemic fatty acid availability will be associated with lower insulin sensitivity and 2) greater systemic fatty acid availability will be associated with greater accumulation of fatty acid intermediates and pro-inflammatory markers.

研究设计

研究类型: Observational
观察模型: Cohort
时间视角: Cross Sectional

入排标准

年龄范围: 18 Years 至 45 Years（Adult）
性别: All
接受健康志愿者: 是

入选标准

•Body mass index [BMI]: 35-45 kg/m2; All women must be pre-menopausal; Non-exerciser (no regularly planned exercise/physical activity)

排除标准

•Weight instability ≥ ±5 lbs. in past month; medications known to affect lipid and/or glucose metabolism; Pregnancy or actively breast feeding

结局指标

主要结局

Insulin Sensitivity

时间窗: 2-3 hours

A hyperinsulinemic-euglycemic clamp will be used to assess peripheral insulin sensitivity

次要结局

Resting Metabolic Rate(20-30 min)

研究者

发起方

University of Michigan

申办方类型

Other

责任方

Principal Investigator

主要研究者

Jeffrey F Horowitz

Associate Professor, Movement Science, School of Kinesiology

University of Michigan

研究点 (1)

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