NCT01301235已完成不适用
Defining 31Phosphorous Magnetic Resonance Spectroscopy Characteristics of the Vastus Lateralis After Sub-maximal Exercise in Patients With Mitochondrial Myopathy
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 8
- 试验地点
- 1
- 主要终点
- PCr recovery after submaximal exercise by 31P-MRS
研究概览
简要总结
This is a developmental protocol to determine the MRI based 31P-MRS changes seen in subjects with mitochondrial myopathy using our dynamic exercise protocol and to identify the ideal variable(s) to represent mitochondrial function.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Men and women ≥ age 18 years old with primary mitochondrial myopathy
- •Known alteration in electron transport chain activity (<25 % activity of ETC) or known mutations in mitochondrial gene.
排除标准
- •Failure based on standard clinical MRI Screening form - the form is intended to establish the safety of subjects participating in the MRI scan without divulging any confidentiality information -
结局指标
主要结局
PCr recovery after submaximal exercise by 31P-MRS
时间窗: 1 year
次要结局
未报告次要终点
研究者
Amy Fleischman, MD
Clinical Investigator
Massachusetts General Hospital
研究点 (1)
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