Impact of Computer-aided Detection System on the Proximal Adenoma Miss Rate: a Multicenter Tandem Rondomized Controlled Trial

1. Study Centers 1) Nanfang Hospital, Southern Medical Univerisity, Guangzhou, China 2) The Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai, China 3) Longgang District People's Hospital of Shenzhen, Shenzhen, China 4) Yangjiang People's Hospital, Yangjiang, China 5) Jiangmen Central Hospital, Jiangmen, China 6) Huizhou Third People's Hospital, Huizhou, China 7) Dongguan Shuixiang Central Hospital, Dongguang, China 8) Pingshan District People's Hospital of Shenzhen, Shenzhen, China

2. Study population 1) Inclusion criteria:

3. Patients age 40-75 years old, regardless of gender

4. Patients presenting for physical examination, colorectal cancer screening or diagnosis

5. Patients voluntarily signs an informed consent form 2) Exclusion criteria:

1. Unable to cooperate ot tolerate colonoscopy
2. History of inflammatory bowel disease
3. History of colorectal cancer
4. Previous colorectal surgery
5. History of recurrent constipation
6. Taking anticoagulant and antiplatelet drugs berfore procedure
7. High risk conditions such as severe cardiovascular and cerebrovascular diseases, severe anemia, or uncorrected infections
8. Pregnant or lactating women Researchers concluded that patient was not suitable to participate in this trial.

3) Post-randomization exclusion criteria: