Influence of COVID-19 on Vascular Endothelial Function
试验速览
- 阶段
- 不适用
- 入组人数
- 203
- 试验地点
- 1
- 主要终点
- Endothelial dysfunction
研究概览
简要总结
Rationale: Infection with severe acute respiratory syndrome coronavirus (SARS-CoV) 2 could result in endothelial dysfunction with increased risk of arterial thrombotic events by downregulating the expression of angiotensin converting enzyme 2 (ACE2). Endothelial function can be easily and non-invasively determined by carotid artery reactivity (CAR) testing.
Objective: To investigate the predictive value of endothelial dysfunction, measured by carotid artery reactivity testing, for 1-year cardiovascular events in patients with past COVID-19 infection.
Study design: A prospective observational longitudinal cohort study.
Study population: Patients recovered from confirmed infection with SARS-CoV2.
Main study parameters/endpoints: macrovascular endothelial function measured by carotid artery reactivity testing.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 16 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Confirmed SARS-CoV2 infection by polymerase chain reaction on nasopharyngeal swab, sputum or bronchoalveolar lavage.
- •At least 6 and no more than 20 weeks after resolution of COVID-19 related symptoms
- •≥ 16 years old
排除标准
- •Recent (<3 months) angina pectoris, myocardial infarction, stroke, or heart failure
- •Raynaud syndrome, scleroderma, complex regional pain syndrome of the upper extremity or presence of arteriovenous fistula or open wounds on both the upper extremities.
结局指标
主要结局
Endothelial dysfunction
时间窗: CAR will be measures between 6 and 20 weeks and 1 year after recovery from COVID-19.
Change in endothelial dysfunction as determined by CAR test.
次要结局
- Major adverse cardiovascular events (MACE)(1 year)