Comparison Study of Echocardiography and Cardiovascular Magnetic Resonance Imaging in the Assessment of Mitral and Aortic Regurgitation
试验速览
- 阶段
- 不适用
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- Correlation of echocardiography and MRI
研究概览
简要总结
The primary treatment for patients determined to have severe aortic or mitral regurgitation is surgical repair or replacement their valves. The most commonly used tool to quantify the severity mitral and aortic regurgitation is echocardiography. Studies have shown that echocardiography may have significant limitations in quantifying regurgitant volume. MRI has recently been shown to easily and reproducibly quantify regurgitation. To better understand how to accurately quantify severity of regurgitation the investigators propose this study with the following aims: 1) compare MRI to echocardiography in the evaluation of regurgitant volume in patients with aortic or mitral regurgitation and 2) to assess which technique is better at predicting the response of the left ventricle to valve surgery.
详细描述
The primary treatment for patients determined to have severe aortic or mitral regurgitation is surgical repair or replacement their valves. The most commonly used tool to quantify the severity mitral and aortic regurgitation is echocardiography. Studies have shown that echocardiography may have significant limitations in quantifying regurgitant volume. MRI has recently been shown to easily and reproducibly quantify regurgitation. To better understand how to accurately quantify severity of regurgitation the investigators propose this study with the following aims: 1) compare MRI to echocardiography in the evaluation of regurgitant volume in patients with aortic or mitral regurgitation and 2) to assess which technique is better at predicting the response of the left ventricle to valve surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age ≥18 years of age
- •Able to give informed consent
- •Referred for isolated aortic or mitral valve repair or replacement due to valve regurgitation
排除标准
- •Inability to provide consent.
- •Pregnancy
- •Claustrophobia
- •Metallic contraindications to MRI (e.g. noncompatible aneurysm clip etc)
- •Known intracardiac shunt
- •Planned concomitant cardiac surgical procedure such as coronary artery bypass, septal myomectomy, or other valve procedure.
- •More than mild mitral or aortic stenosis.
- •For patients enrolled with mitral regurgitation: greater than mild aortic regurgitation.
- •For patients enrolled with aortic regurgitation: greater than mild mitral regurgitation.
- •Hypertrophic cardiomyopathy.
结局指标
主要结局
Correlation of echocardiography and MRI
时间窗: 6 month
Correlation of echocardiography and MRI
Change in LV EDV post surgery
时间窗: 6 month
Change in LV EDV post surgery
次要结局
未报告次要终点
研究者
Seth Uretsky
Medical Director, Cardiovascular Imaging
Atlantic Health System
