The Influence of Postoperative Cognitive Function in Patients With Sevoflurane Postconditioning on Carotid Intima Stripped
试验速览
- 阶段
- 早期 1 期
- 发起方
- 入组人数
- 140
- 试验地点
- 1
- 主要终点
- Change from the 1 day preoperative to the 1 day postoperative MoCA(Montreal Cognitive Assessment)
研究概览
简要总结
Brief summary: In order to get a better clinical plan for brain protection during perioperative anesthesia for high-risk patients - carotid intima stripped. We observing the hemodynamic changes of sevoflurane post-treatment in carotid intima stripped, the comparison of postoperative cognitive function and postoperative radiographic changes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 50 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologists（ASA）：II-III
- •Aged between 40 and 80 years
- •Patients scheduled for surgery of Carotid stenosis under general anaesthesia
排除标准
- •Has a history of mental illness can't cooperate,
- •Serious heart block or cardiac decompensation or severe sinus slow (HR < 50 times/min),
- •The abnormal nerve monitoring in operation, MMES preoperative score < 20 points,
- •Any rescue unexpected occurred during the operation
研究组 & 干预措施
Sevoflurane post conditioning group（S1）
propofol：0.05～0.1mg/(kg.min) maintain throughout the whole surgery ,1% sevoflurane plus after open Carotid artery until the end of surgery
干预措施: Sevoflurane inhalant product (Drug)
结局指标
主要结局
Change from the 1 day preoperative to the 1 day postoperative MoCA(Montreal Cognitive Assessment)
时间窗: Time Frame: the 1st day before the surgery；the 1st day after the surgery
Screening scale of cognitive function。The highest score is 30 points，Add 1 score, education the following subjects in less than 12 years。Total score less than 26 divided into cognitive dysfunction。Compared with MMSE, more sensitive to mild dementia。
Change from the 1 day preoperative to the 1 day postoperative MMSE(Mini-mental State Examination)
时间窗: the 1st day before the surgery；the 1st day after the surgery
Screening scale of cognitive function。The highest score is 30 points, 27 to 30 were divided into normal, less than 27 divided into cognitive dysfunction。But is not sensitive in the early identification of dementia, especially in mild cognitive impairment is poorer.
次要结局
- Cerebral oxygen saturation(Ten minutes before induction（T0) ,Intraoperative (Before the carotid artery occlusion（T1）), Intraoperative (before open the Carotid artery（T2)，At the end of the surgery when the surgeon completed sewing skin（T3），the 24 hours after the operation（T4）)
- PETCO2(Ten minutes before induction（T0) ,Intraoperative (Before the carotid artery occlusion（T1）), Intraoperative (before open the Carotid artery（T2)，At the end of the surgery when the surgeon completed sewing skin（T3），the 24 hours after the operation（T4）)
- Invasive arterial blood pressure(Ten minutes before induction（T0) ,Intraoperative (Before the carotid artery occlusion（T1）), Intraoperative (before open the Carotid artery（T2)，At the end of the surgery when the surgeon completed sewing skin（T3），the 24 hours after the operation（T4）)
- BIS(Ten minutes before induction（T0) ,Intraoperative (Before the carotid artery occlusion（T1）), Intraoperative (before open the Carotid artery（T2)，At the end of the surgery when the surgeon completed sewing skin（T3），the 24 hours after the operation（T4）)
- Heart rate(Ten minutes before induction（T0) ,Intraoperative (Before the carotid artery occlusion（T1）), Intraoperative (before open the Carotid artery（T2)，At the end of the surgery when the surgeon completed sewing skin（T3），the 24 hours after the operation（T4）)