The Effects of High-intensity Interval Exercise and Chocolate Milk on Glycemic Control and Cognitive Function in Children.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Change from baseline Glycemic Response
研究概览
简要总结
The purpose of this study is to determine the separate and combined effects of high-intensity interval exercise and chocolate milk on glycemic response, cognitive function, subjective appetite, and salivary cortisol among children aged 9-13 year old children.
详细描述
Twenty children 9-13 years of age will be recruited for this study. On four separate mornings, after a 10 hour overnight fast, each child will consume a standardized breakfast (including orange juice, a strawberry breakfast bar and a pear fruit cup) at home. Using a 2x2 factorial design, 2 hours after breakfast consumption, each participant will arrive in the lab (T=-20 min) and participate in high-intensity interval exercise or sit quietly for 20 min, followed by a treatment drink of chocolate milk or water (control) consumption in 10 min. During high-intensity interval exercise treatment, children will exercise on a cycle ergometer with a 3-min warm-up, 7 repeated bouts of 60-sec exercise at 90% of peak power output and 60-second recovery, and a 3-min cool down. Blood glucose will be measured via finger-prick at baseline (-20 min), 10, 30, 60, and 90 min. Cognitive functions will be measured using a battery of cognitive tests which assess verbal declarative memory, working memory, and executive functioning, and will be measured at baseline, 10. 30. 60, and 90 min. Subjective appetite and emotions will be measured using a 100-mm visual analogue scale (VAS) at baseline, 10, 30, 60, and 90 min. Salivary cortisol will be assessed from saliva samples collected using the passive drool method, and will be collected at baseline, 10 and 30 min.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 9 Years 至 13 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •be between 9 and 13 years of age
- •be healthy, and have been born at term
- •not be taking any medications
- •not have allergies to dairy or gluten.
排除标准
- •Food sensitivities, allergies, or dietary restrictions
- •Health, learning, emotional, or behavioural problems
- •Receiving any medications
- •Non-habitual breakfast eater (<5 days/week)
研究组 & 干预措施
Exercise and Chocolate Milk
Children will exercise on a cycle ergometer with a 3-min warm-up, 7 repeated bouts of 60-sec exercise at 90% of peak power output and 60-second recovery, and a 3-min cool down.
Children will then drink 240mL of chocolate milk
干预措施: Exercise and Chocolate Milk (Other)
Exercise and Water
Children will exercise on a cycle ergometer with a 3-min warm-up, 7 repeated bouts of 60-sec exercise at 90% of peak power output and 60-second recovery, and a 3-min cool down.
Children will then drink 240mL of water
干预措施: Exercise and Water (Other)
Sitting and Chocolate Milk
Children will quietly sit for 20 minutes Children will then drink 240mL of chocolate milk
干预措施: Sitting and Chocolate Milk (Other)
Sitting and Water
Children will quietly sit for 20 minutes Children will then drink 240mL of water
干预措施: Sitting and Water (Other)
结局指标
主要结局
Change from baseline Glycemic Response
时间窗: baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption
Blood samples will be collected via finger-prick method to assess glycemic response (blood glucose, mmol/L)
Change from baseline working memory
时间窗: baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption
The n-back test consists of 2 levels, 1-back and 2-back, where letters are presented on the screen one at a time. During the 1-back level, participants need to determine if the presented letter is the same as the one letter presented 1 before it or not (by selected 'match' or 'no match' on the side of the screen) and during 2-back need to do determine if it is the same letter as the one presented 2 letters prior.
Change from baseline verbal declarative memory
时间窗: baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption
Cognitive function test of verbal declarative memory
Change from baseline executive functioning
时间窗: baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption
The Stroop test consists of one word appearing on the screen written in either blue, red, yellow or green. There are 24 congruent trials where the presented word is the name of the colour it is written it (i.e. 'red' appearing in the colour red), 24 incongruent trials where the word written is a colour word different from the one it is written in (i.e. 'red' appearing in the colour green), and 10 neutral trials where non-colour words appear (i.e. 'tape' appearing in yellow). The participant is asked to tap the corresponding colour that the word is written in as quickly as possible.
次要结局
- Change from baseline tension(baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption)
- Change from baseline anger(baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption)
- Change from baseline disappointment(baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption)
- Change from baseline aggression(baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption)
- Change from baseline sleepiness(baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption)
- Change from baseline salivary cortisol response(baseline (-20 min), and 10 and 30 min post-drink consumption)
- Change form baseline Subjective Appetite(baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption)
- Change from baseline excitement(baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption)
- Change from baseline upset(baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption)
- Change from baseline exhaustion(baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption)
- Change from baseline happiness(baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption)
- Change form baseline frustration(baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption)
- Change from baseline alertness(baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption)
- Change from baseline sadness(baseline (-20 min), and 10, 30, 60, and 90 min post-drink consumption)
研究者
Nick Bellissimo
Study Director
Toronto Metropolitan University