The Relationship Between Lung and Gut Microbiome in Chronic Obstructive Pulmonary Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Microbiota that can predict the progress of lung function
研究概览
简要总结
Increasing evidence have implied that microbiota from airway and gut might be involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, the cross-talk between respiratory and gastrointestinal microbiome in COPD is still undetermined. The study is aimed to investigate the interaction between lung and gut flora, and their role in the process of COPD.
详细描述
Despite the high prevalence of chronic obstructive pulmonary disease (COPD), there continues to be a large gap in our understanding of disease pathogenesis and mechanisms accounting for large variability in disease phenotype. Cigarette smoking is the principal cause of COPD, but only approximately 15% of adults with substantial tobacco exposure develop clinical COPD. Besides, bacterial colonization or infection is also considered as an important factor in COPD. There are very limited data from microbiome studies that suggest that respiratory and gastrointestinal microbiota may be involved in the pathogenesis of COPD. However, the cross-talk between between lung and gut microbiome, and their relationship with various clinical phenotypes of COPD. Here, we conducted 16S rRNA-based pyrosequencing to evaluate the link between the lung-gut axis and the clinical phenotypes of COPD, such as lung function, emphysema, symptoms, exacerbations, inflammation levels and metabolic features.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •males aged 40-80;
- •diagnosed with COPD according to the GOLD guidelines;
- •clinically stable patients without medication changes or exacerbation in two months;
- •smoking history of more than 10 pack years
排除标准
- •diagnosed with unstable cardiovascular diseases, significant renal or hepatic dysfunction or mental incompetence;
- •diagnosed with asthma, active pulmonary tuberculosis, diffuse panbronchiolitis, cystic fibrosis, clinically significant bronchiectasis, exacerbation of COPD or pneumonia in two months;
- •prescribed immunosuppressive medications.
结局指标
主要结局
Microbiota that can predict the progress of lung function
时间窗: 6 months
The study is aimed to investigate the relationship between the microbiota and the progress of lung function in COPD
次要结局
- Bacteria related to metabolomics(6 months)
- Bacteria related to inflammatory factors(6 months)
研究者
Bei He
Professor and Chief in Department of Respiratory Medicine
Peking University Third Hospital