Prognostic Impact of Surgical Resection Extent for Supratentorial High Grade Gliomas.
试验速览
- 阶段
- 不适用
- 入组人数
- 28
- 主要终点
- Clinical picture using Modified Rankin's Scale (mRS).
研究概览
简要总结
Prospective randomized controlled clinical trials (single arm study) of surgical treatment modalities for supratentorial high grade gliomas within the next two years.
详细描述
Supratentorial high grade gliomas are for surgical resection in any case according to many factors.
Investigators will compare the outcomes/survival rate and clinical outcome of the different resection types (Total, near total, subtotal/debulking) of supratentorial high grade gliomas according to the clinical condition and comorbidities of the patient, the location and morphology of the lesion, the grading of lesions, and the clinical experience of the neurosurgeon.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who will undergo surgical excision of the supratentorial high grade gliomas at the time of study (two years).
- •Denovo disease for the first time.
排除标准
- •Low-grade Gliomas.
- •Infratentorial high-grade gliomas.
- •Past history of gliomas.
- •Patients who are unfit for any neurosurgical interventions.
- •Patients who do not receive their adjuvant standard therapy.
结局指标
主要结局
Clinical picture using Modified Rankin's Scale (mRS).
时间窗: 1 year
The changes in clinical condition of the patients will be assessed using Modified Rankin's Scale (mRS) before and after treatment. The scale runs from 0-6, running from perfect health without symptoms to death. 0 - No symptoms. 1. - No significant disability. Able to carry out all usual activities, despite some symptoms. 2. - Slight disability. Able to look after own affairs without assistance, but unable to carry out all previous activities. 3. - Moderate disability. Requires some help, but able to walk unassisted. 4. - Moderately severe disability. Unable to attend to own bodily needs without assistance, and unable to walk unassisted. 5. - Severe disability. Requires constant nursing care and attention, bedridden, incontinent. 6. - Dead.
次要结局
- Recurrence or increased residual(within 3 months after treatment)
研究者
Amr Badary
Resident Doctor
Assiut University