Effects of Creatine and Glucoseamine/ Chondritin Sulfate Co-Supplementation in Addition to Exercise and Physical Therapy in Patients With Knee Osteoarthritis
试验速览
- 阶段
- 不适用
- 入组人数
- 36
- 试验地点
- 2
- 主要终点
- Six Minute Walk Test
研究概览
简要总结
Osteoarthritis is the 11th highest contributor to disability world wide. In terms of conservative management of patients with knee osteoarthritis, Resistance exercise has been shown to be an effective intervention for reducing pain and cartilage degeneration and improving muscle strength, joint biomechanics and physical functioning. But, research shows that co supplementation can further augment the effects of resistance exercise. However, it is imperative to point out that the existing evidence is majorly focused on the individual effects of resistance exercise training and non-pharmacological supplementation, and is still deficient in the effects of co-supplementation in addition to resistance exercise training in patients with knee osteoarthritis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 40 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 40-70 years
- •Knee OA with history not less than three months.
- •Radiological evidences of grade III or less on Kellgren classification.
- •Knee pain on VNRS no more than 8/10
排除标准
- •Neuromuscular conditions that may lead to fatigue such as multiple Sclerosis
- •Signs of serious pathology (e.g., malignancy, inflammatory disorder, infection).
- •History of trauma or fractures in lower extremity.
- •Signs of lumbar radiculopathy or myelopathy.
- •History of knee surgery or replacement.
- •Patients on intra-articular steroid therapy within two months before the commencement of the study.
- •Impaired skin sensation.
- •Impaired renal function
结局指标
主要结局
Six Minute Walk Test
时间窗: 4 weeks
Six Minute Walk Test will be used to quantify walking related performance fatigability, walkind distance and walking speed.
Knee Pain: Numeric Pain Rating Scale
时间窗: 4 weeks
Knee Pain will be quantified by using Numeric Pain Rating Scale
Knee Range of Motion
时间窗: 4 weeks
Knee Range of Motion will be quantified by using Gonimeter
Knee Isometric Muscle Strength
时间窗: 4 weeks
Knee Isometric Muscle Strength will be quantified by using Modified Sphygmomanometer Dynamometer
次要结局
- Knee Injury and Osteoarthritis Outcome Score (KOOS)(4 weeks)
- Postural Stability(4 weeks)
- Body Composition(4 weeks)
- Fall Risk(4 weeks)