Compensatory Brain Mechanisms for Amygdala-associated Cognitive Dysfunction: Potential Role of the Cortical Mirror Neuron System
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 350
- 试验地点
- 1
- 主要终点
- brain activity and connectivity during social and cognitive tasks
研究概览
简要总结
Identify if the mirror neuron system, or other networks, can compensate for amygdala dysfunction, using behavior and structural/functional MRI.
详细描述
In the present study, investigators aim to investigate amygdala dysfunction & potential compensation in individuals with high and low traits (e.g. Autism, Anxiety, Depression traits, Alexithymia), high and low stress or protective factors in the environment (social network, early life stress) and different molecular genetic make-up. On the neural level, functional and structural connectivity as well as task-related BOLD activation will be assessed.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 17 Years 至 30 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy subjects
排除标准
- •history of head injury
- •claustrophobia;
- •medical or psychiatric illness
- •female subjects were pregnant or taking oral contraceptives.
- •taking any form of medication and drunk any caffeine-containing beverages on the day of the experiment.
结局指标
主要结局
brain activity and connectivity during social and cognitive tasks
时间窗: 2 hours
brain activity and connectivity was measured by the fMRI scanner
次要结局
未报告次要终点
研究者
Keith Kendrick
Professor
University of Electronic Science and Technology of China