Combating Alzheimer's Through Sleep and Exercise (CASE)
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Creatinine Levels
研究概览
简要总结
The purpose of this research is to see how sleep and exercise affects dementia risk over time.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 45 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Able to perform mild exercise
- •Able to wear DREEM 2 Headband
- •Able to wear a Fitbit wrist watch
- •Able to perform the Everlywell biomarker procedure
- •Able to Understand and Speak English
- •Able to operate a digital device like mobile phone, iPad, or computer
- •Self-reported history of problems with cognitive impairment: memory, concentration, and processing information
- •Only participants cognitively able and willing to provide consent will be included.
排除标准
- •Prohibited from or unable to perform mild exercise
- •Unable to wear wrist watch or headband devices, or unable to supply pinprick blood sample for any reason
- •Unable to speak or understand English
- •Unable to use mobile device/smartphone technology
- •Unable or unwilling to consent for any reason.
研究组 & 干预措施
Exercise and Sleep Group
Participants in this group will take part in a guided exercise program in additional to wearing the DREEM 2 headband for 12 weeks.
干预措施: Exercise Routine (Other)
Sleep Only Group
Participants in this group will wear the DREEM 2 headband for 12 weeks.
干预措施: DREEM 2 Headband (Device)
Exercise Only Group
Participants in this group will workout twice a week for 12 weeks.
干预措施: Exercise Routine (Other)
Exercise and Sleep Group
Participants in this group will take part in a guided exercise program in additional to wearing the DREEM 2 headband for 12 weeks.
干预措施: DREEM 2 Headband (Device)
结局指标
主要结局
Creatinine Levels
时间窗: Up to Week 12
Measured from Urine Sample
HbA1c Levels
时间窗: Up to Week 12
Measured from blood sample
Heart Rate
时间窗: Up to Week 12
Measured from Fitbit
Total Sleep Duration
时间窗: Up to Week 12
Measured from DREEM 2
Slow Wave Sleep Duration
时间窗: Up to Week 12
Measured from DREEM 2
Triglycerides Levels
时间窗: Up to Week 12
Measured from blood sample
High-Density Lipoprotein (HDL) Levels
时间窗: Up to Week 12
Measured from blood sample
Blood Pressure
时间窗: Up to Week 12
Measured from Fitbit
Cortisone Levels
时间窗: Up to Week 12
Measured from Urine Sample
Total Cholesterol Levels
时间窗: Up to Week 12
Measured from blood sample
Low-Density Lipoprotein (LDL) Levels
时间窗: Up to Week 12
Measured from blood sample
High-sensitivity C-reactive protein (hs-CRP) Levels
时间窗: Up to Week 12
Measured from blood sample
Cortisol Levels
时间窗: Up to Week 12
Measured from Urine Sample
Melatonin Levels
时间窗: Up to Week 12
Measured from Urine Sample
次要结局
未报告次要终点
研究者
Azizi Seixas
Associate Professor
University of Miami